Andrew Kleinberg
Overview
Explore the profile of Andrew Kleinberg including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
42
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kleinberg A, Mao Y, Li N
MAbs
. 2024 Oct;
16(1):2420805.
PMID: 39460736
Non-reduced peptide mapping provides essential data for characterizing therapeutic monoclonal antibodies by isolating disulfide connections between specific cysteines. However, conventional digestive strategies used throughout the biopharmaceutical industry have been shown...
2.
Zhong X, Gao L, Kleinberg A, Mao Y, Lawrence S, Bak H, et al.
J Pharm Sci
. 2023 Nov;
113(3):642-646.
PMID: 37913905
The percentage of trisulfide variants is a product quality metric that is monitored during the manufacture of monoclonal antibody (mAb)-based therapeutics. Results from earlier preclinical studies revealed that trisulfide linkages...
3.
Kleinberg A, Joseph R, Mao Y, Li N
Anal Biochem
. 2022 Jun;
653:114773.
PMID: 35688259
Explicitly confirming the complete disulfide bond linkage pattern of a monoclonal antibody (mAb) presents a challenge in the biopharmaceutical industry. Although proper native disulfide connections are in high abundance for...
4.
Mao Y, Kleinberg A, Li N
Anal Chem
. 2020 Jun;
92(14):9682-9690.
PMID: 32559367
Peptide mapping coupled with liquid chromatography-mass spectrometry (LC-MS) has become an essential analytical technique to quantify the quality attributes (e.g., post-translational modifications [PTMs]) of monoclonal antibodies (mAbs) during drug development....
5.
Mao Y, Kleinberg A, Zhao Y, Raidas S, Li N
Anal Chem
. 2020 May;
92(13):8691-8696.
PMID: 32463663
Trifluoroacetic acid (TFA) is a commonly used mobile phase additive in liquid chromatography-mass spectrometry (LC-MS)-based biopharmaceutical characterization to enhance reversed-phase chromatographic performance of peptide separation; however, it leads to significant...
6.
Mao Y, Zhang L, Kleinberg A, Xia Q, Daly T, Li N
MAbs
. 2019 Mar;
11(4):767-778.
PMID: 30919719
Growth in the pharmaceutical industry has led to an increasing demand for rapid characterization of therapeutic monoclonal antibodies. The current methods for antibody sequence confirmation (e.g., N-terminal Edman sequencing and...
7.
Jin M, Petronella B, Cooke A, Kadalbajoo M, Siu K, Kleinberg A, et al.
ACS Med Chem Lett
. 2014 Jun;
4(7):627-31.
PMID: 24900721
This letter describes a series of small molecule inhibitors of IGF-1R with unique time-dependent binding kinetics and slow off-rates. Structure-activity and structure-kinetic relationships were elucidated and guided further optimizations within...
8.
Jin M, Gokhale P, Cooke A, Foreman K, Buck E, May E, et al.
ACS Med Chem Lett
. 2014 Jun;
1(9):510-5.
PMID: 24900240
This report describes the investigation of a series of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR). Structure-activity relationship exploration and optimization leading to the...
9.
Hornberger K, Chen X, Crew A, Kleinberg A, Ma L, Mulvihill M, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4511-6.
PMID: 23856049
The kinase selectivity and pharmacokinetic optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. The intersection of insights from molecular modeling, computational prediction of metabolic sites, and in...
10.
Hornberger K, Berger D, Crew A, Dong H, Kleinberg A, Li A, et al.
Bioorg Med Chem Lett
. 2013 Jul;
23(16):4517-22.
PMID: 23850198
The discovery and potency optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. Micromolar hits taken from high-throughput screening were optimized for biochemical and cellular mechanistic potency to...