Mark Cushman
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Explore the profile of Mark Cushman including associated specialties, affiliations and a list of published articles.
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183
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2467
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Recent Articles
1.
Han Y, Buric A, Chintareddy V, DeMoss M, Chen L, Dickerhoff J, et al.
J Med Chem
. 2024 Apr;
67(9):7006-7032.
PMID: 38668707
G-quadruplexes are noncanonical four-stranded DNA secondary structures. is a master oncogene and the G-quadruplex formed in the promoter functions as a transcriptional silencer and can be stabilized by small molecules....
2.
Liu X, Lv W, Zhao F, Ding J, Zhang J, Xue F, et al.
Bioorg Med Chem Lett
. 2022 Apr;
68:128761.
PMID: 35483593
Resistance to telithromycin and off-target effects associated with the metabolic instability present serious and challenging problems for the development of novel macrolides. Herein, studies of hybrids of macrolides and quinolones...
3.
Cushman M
J Med Chem
. 2021 Dec;
64(24):17572-17600.
PMID: 34879200
The discovery that certain indenoisoquinolines inhibit the religation reaction of DNA in the topoisomerase I-DNA-indenoisoquinoline ternary complex led to a structure-based drug design research program which resulted in three representatives...
4.
Fan B, Hiasa H, Lv W, Brody S, Yang Z, Aldrich C, et al.
Eur J Med Chem
. 2020 Mar;
193:112222.
PMID: 32200200
In the search for novel hybrid molecules by fusing two biologically active scaffolds into one heteromeric chemotype, we found that hybrids of azithromycin and ciprofloxacin/gatifloxacin 26j and 26l can inhibit...
5.
Reguera R, Alvarez-Velilla R, Dominguez-Asenjo B, Gutierrez-Corbo C, Balana-Fouce R, Cushman M, et al.
BMC Vet Res
. 2019 Nov;
15(1):405.
PMID: 31706354
Background: Canine leishmaniasis is a zoonotic disease caused by Leishmania infantum, being the dogs one of the major reservoirs of human visceral leishmaniasis. DNA topology is a consolidated target for...
6.
Gutierrez-Corbo C, Alvarez-Velilla R, Reguera R, Garcia-Estrada C, Cushman M, Balana-Fouce R, et al.
Int J Parasitol Drugs Drug Resist
. 2019 Sep;
11:39-48.
PMID: 31563118
DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines, a family of non-camptothecinic based topoisomerase poisons, have a strong leishmanicidal effect both...
7.
Wang K, Elsayed M, Wu G, Deng N, Cushman M, Yang D
J Am Chem Soc
. 2019 Jul;
141(28):11059-11070.
PMID: 31283877
is one of the most important oncogenes and is overexpressed in the majority of cancers. G-Quadruplexes are noncanonical four-stranded DNA secondary structures that have emerged as attractive cancer-specific molecular targets...
8.
Li X, Lv W, Guo S, Li Y, Fan B, Cushman M, et al.
Eur J Med Chem
. 2019 Mar;
171:235-254.
PMID: 30925339
In general, potent non-ketolide versions of erythromycin possessed conformationally constricted two- or three-atom-length sidechains at 3-OH. Novel 14-membered non-ketolides possessing long spacers beyond three-atom length were evaluated for antibacterial activity....
9.
Ma C, Lv W, Li Y, Fan B, Han X, Kong F, et al.
Eur J Med Chem
. 2019 Mar;
169:1-20.
PMID: 30852383
Constitutively erythromycin-resistant apathogens are more difficult to address than inducibly resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime erythromycin ketolides were synthesized and evaluated. Incorporation of...
10.
Pommier Y, Cushman M, Doroshow J
Oncotarget
. 2019 Jan;
9(99):37286-37288.
PMID: 30647868
No abstract available.