Mariana D Mandler
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Explore the profile of Mariana D Mandler including associated specialties, affiliations and a list of published articles.
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11
Citations
471
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Recent Articles
1.
Mandler M, Kulkarni S, Batista P
Mol Cell Biol
. 2025 Jan;
:1-8.
PMID: 39757918
RNA modifications are highly conserved across all domains of life, suggesting an early emergence and a fundamental role in cellular processes. The modification 3-(3-amino-3-carboxypropyl)uridine (acp³U) is found in tRNAs of...
2.
Mandler M, Maligireddy S, Guiblet W, Fitzsimmons C, McDonald K, Warrell D, et al.
RNA
. 2024 Apr;
30(8):1025-1040.
PMID: 38684317
RNA modifications have a substantial impact on tRNA function, with modifications in the anticodon loop contributing to translational fidelity and modifications in the tRNA core impacting structural stability. In bacteria,...
3.
Mandler M, Maligireddy S, Guiblet W, Fitzsimmons C, McDonald K, Warrell D, et al.
bioRxiv
. 2024 Mar;
PMID: 38529508
RNA modifications have a substantial impact on tRNA function, with modifications in the anticodon loop contributing to translational fidelity and modifications in the tRNA core impacting structural stability. In bacteria,...
4.
Fitzsimmons C, Mandler M, Lunger J, Chan D, Maligireddy S, Schmiechen A, et al.
NAR Cancer
. 2024 Feb;
6(1):zcae004.
PMID: 38328795
Metabolic reprogramming is a hallmark of cancer that facilitates changes in many adaptive biological processes. Mutations in the tricarboxylic acid cycle enzyme fumarate hydratase (FH) lead to fumarate accumulation and...
5.
Chan D, Fitzsimmons C, Mandler M, Batista P
PLoS Comput Biol
. 2021 Jun;
17(6):e1009057.
PMID: 34166364
No abstract available.
6.
Nanan K, Sturgill D, Prigge M, Thenoz M, Dillman A, Mandler M, et al.
iScience
. 2019 Aug;
19:326-339.
PMID: 31404833
The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative, 5-carboxylcytosine (5caC), as a factor driving new CTCF binding within genomic DNA....
7.
Arango D, Sturgill D, Alhusaini N, Dillman A, Sweet T, Hanson G, et al.
Cell
. 2018 Nov;
175(7):1872-1886.e24.
PMID: 30449621
Generation of the "epitranscriptome" through post-transcriptional ribonucleoside modification embeds a layer of regulatory complexity into RNA structure and function. Here, we describe N4-acetylcytidine (ac4C) as an mRNA modification that is...
8.
Nanan K, Ocheltree C, Sturgill D, Mandler M, Prigge M, Varma G, et al.
Nucleic Acids Res
. 2017 Dec;
45(22):12780-12797.
PMID: 29244186
Actively transcribed genes adopt a unique chromatin environment with characteristic patterns of enrichment. Within gene bodies, H3K36me3 and cytosine DNA methylation are elevated at exons of spliced genes and have...
9.
Mandler M, Ku L, Feng Y
Nucleic Acids Res
. 2014 May;
42(11):7319-29.
PMID: 24792162
The selective RNA-binding protein quaking I (QKI) plays important roles in controlling alternative splicing (AS). Three QKI isoforms are broadly expressed, which display distinct nuclear-cytoplasmic distribution. However, molecular mechanisms by...
10.
Bankston A, Mandler M, Feng Y
Neurosci Bull
. 2013 Apr;
29(2):216-28.
PMID: 23558590
Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conduction, the...