Shalini Oberdoerffer
Overview
Explore the profile of Shalini Oberdoerffer including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
1618
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Recent Articles
1.
Oberdoerffer S, Gilbert W
Nat Rev Mol Cell Biol
. 2024 Nov;
26(3):249.
PMID: 39533117
No abstract available.
2.
Oberdoerffer S, Gilbert W
Nat Rev Mol Cell Biol
. 2024 Oct;
26(3):237-248.
PMID: 39433914
RNA modifications are essential for human health - too much or too little of them leads to serious illnesses ranging from neurodevelopmental disorders to cancer. Technical advances in RNA modification...
3.
Achour C, Oberdoerffer S
Curr Opin Genet Dev
. 2024 May;
87:102207.
PMID: 38820741
N4-acetylcytidine (ac4C) is an RNA modification that is catalyzed by the enzyme NAT10. Constitutively found in tRNA and rRNA, ac4C displays a dynamic presence in mRNA that is shaped by...
4.
Relier S, Schiffers S, Beiki H, Oberdoerffer S
RNA
. 2024 May;
30(7):938-953.
PMID: 38697668
The functional analysis of epitranscriptomic modifications in RNA is constrained by a lack of methods that accurately capture their locations and levels. We previously demonstrated that the RNA modification N4-acetylcytidine...
5.
Beiki H, Sturgill D, Arango D, Relier S, Schiffers S, Oberdoerffer S
Mol Cell
. 2024 Apr;
84(8):1611-1625.e3.
PMID: 38640896
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). Our results contradicted an...
6.
Schiffers S, Oberdoerffer S
RNA
. 2024 Mar;
30(5):583-594.
PMID: 38531654
In recent years, concerted efforts to map and understand epitranscriptomic modifications in mRNA have unveiled new complexities in the regulation of gene expression. These studies cumulatively point to diverse functions...
7.
Chen L, Ingolia N, Insco M, Li J, Oberdoerffer S, Weeks K
Cell Chem Biol
. 2024 Jan;
31(1):10-13.
PMID: 38242091
In the first of many thematic issues marking the 30 anniversary of Cell Chemical Biology, we highlight the contribution of chemical biology to RNA biology in a special issue on...
8.
Sturgill D, Arango D, Oberdoerffer S
STAR Protoc
. 2023 Jan;
3(4):101858.
PMID: 36595942
N4-acetylcytidine (ac4C) is an mRNA modification catalyzed by the enzyme N-acetyltransferase 10 (NAT10), with position-dependent effects on mRNA translation. This protocol details a procedure to map ac4C at base resolution...
9.
Arango D, Sturgill D, Yang R, Kanai T, Bauer P, Roy J, et al.
Mol Cell
. 2022 Aug;
82(15):2912.
PMID: 35931039
No abstract available.
10.
Arango D, Sturgill D, Yang R, Kanai T, Bauer P, Roy J, et al.
Mol Cell
. 2022 Jun;
82(15):2797-2814.e11.
PMID: 35679869
mRNA function is influenced by modifications that modulate canonical nucleobase behavior. We show that a single modification mediates distinct impacts on mRNA translation in a position-dependent manner. Although cytidine acetylation...