David Sturgill
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Explore the profile of David Sturgill including associated specialties, affiliations and a list of published articles.
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38
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5297
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Recent Articles
1.
Melters D, Bui M, Rakshit T, Grigoryev S, Sturgill D, Dalal Y
Life Sci Alliance
. 2025 Jan;
8(4.
PMID: 39848706
Centromeres are marked by the centromere-specific histone H3 variant CENP-A/CENH3. Throughout the cell cycle, the constitutive centromere-associated network is bound to CENP-A chromatin, but how this protein network modifies CENP-A...
2.
Wang L, Baek S, Prasad G, Wildenthal J, Guo K, Sturgill D, et al.
bioRxiv
. 2024 Sep;
PMID: 39314336
Genetic and epigenetic variations in regulatory enhancer elements increase susceptibility to a range of pathologies. Despite recent advances, linking enhancer elements to target genes and predicting transcriptional outcomes of enhancer...
3.
Beiki H, Sturgill D, Arango D, Relier S, Schiffers S, Oberdoerffer S
Mol Cell
. 2024 Apr;
84(8):1611-1625.e3.
PMID: 38640896
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). Our results contradicted an...
4.
Sturgill D, Wang L, Arda H
BMC Genomics
. 2024 Jan;
25(1):76.
PMID: 38238687
Background: The human pancreas is composed of specialized cell types producing hormones and enzymes critical to human health. These specialized functions are the result of cell type-specific transcriptional programs which...
5.
Sturgill D, Arango D, Oberdoerffer S
STAR Protoc
. 2023 Jan;
3(4):101858.
PMID: 36595942
N4-acetylcytidine (ac4C) is an mRNA modification catalyzed by the enzyme N-acetyltransferase 10 (NAT10), with position-dependent effects on mRNA translation. This protocol details a procedure to map ac4C at base resolution...
6.
Arango D, Sturgill D, Yang R, Kanai T, Bauer P, Roy J, et al.
Mol Cell
. 2022 Aug;
82(15):2912.
PMID: 35931039
No abstract available.
7.
Arango D, Sturgill D, Yang R, Kanai T, Bauer P, Roy J, et al.
Mol Cell
. 2022 Jun;
82(15):2797-2814.e11.
PMID: 35679869
mRNA function is influenced by modifications that modulate canonical nucleobase behavior. We show that a single modification mediates distinct impacts on mRNA translation in a position-dependent manner. Although cytidine acetylation...
8.
Arunkumar G, Baek S, Sturgill D, Bui M, Dalal Y
Sci Adv
. 2022 Mar;
8(9):eabl5621.
PMID: 35235361
Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A plays a fundamental role in defining centromere identity, structure, and function but is innately overexpressed in several...
9.
Heard E, Johnson A, Korbel J, Lee C, Snyder M, Sturgill D
Fac Rev
. 2022 Jan;
10:63.
PMID: 35088059
While the human genome represents the most accurate vertebrate reference assembly to date, it still contains numerous gaps, including centromeric and other large repeat-containing regions - often termed the "dark...
10.
Bruno N, Nwachukwu J, Hughes D, Srinivasan S, Hawkins R, Sturgill D, et al.
FASEB J
. 2021 Nov;
35(12):e21999.
PMID: 34748223
The Creb-Regulated Transcriptional Coactivator (Crtc) family of transcriptional coregulators drive Creb1-mediated transcription effects on metabolism in many tissues, but the in vivo effects of Crtc2/Creb1 transcription on skeletal muscle metabolism...