Marc G Achen
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Explore the profile of Marc G Achen including associated specialties, affiliations and a list of published articles.
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77
Citations
3625
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Recent Articles
1.
Yuan Y, Levy S, Yeo Y, Shayan R, Karnezis T, Stacker S, et al.
iScience
. 2025 Mar;
28(3):111948.
PMID: 40060910
Secondary lymphedema is a debilitating chronic tissue swelling in a limb caused by inadequate interstitial fluid drainage due to dysfunctional lymphatic vessels. Pathological enlargement of small lymphatics contributes to lymphatic...
2.
Pillay V, Shukla L, Herle P, Maciburko S, Bandara N, Reid I, et al.
Front Pharmacol
. 2023 May;
14:1152314.
PMID: 37188266
Surgery and radiotherapy are key cancer treatments and the leading causes of damage to the lymphatics, a vascular network critical to fluid homeostasis and immunity. The clinical manifestation of this...
3.
Ishaq M, Bandara N, Morgan S, Nowell C, Mehdi A, Lyu R, et al.
Int J Obes (Lond)
. 2021 Nov;
46(3):502-514.
PMID: 34764426
Objectives: Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is often mistaken for obesity and causes significant impairment to mobility and quality-of-life. To identify molecular mechanisms underpinning lipedema, we...
4.
He M, Halford M, Liu R, Roy J, Grant Z, Coultas L, et al.
Commun Biol
. 2021 Jul;
4(1):878.
PMID: 34267311
Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant angiogenesis using anti-angiogenic therapy (AAT) has been successful in the clinical treatment of cancer and eye...
5.
Arcucci V, Stacker S, Achen M
Biomolecules
. 2021 Feb;
11(2).
PMID: 33572413
Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumour metastasis and poor patient prognosis. Many factors regulate angiogenesis and lymphangiogenesis in cancer including...
6.
Vogrin A, Bower N, Gunzburg M, Roufail S, Okuda K, Paterson S, et al.
Cell Rep
. 2019 Aug;
28(8):2023-2036.e4.
PMID: 31433980
Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner....
7.
Yuan Y, Arcucci V, Levy S, Achen M
Front Immunol
. 2019 Feb;
10:76.
PMID: 30761143
The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treatment of cancer. These therapies can damage lymphatic vessels leading to edema, fibrosis, inflammation and...
8.
Karnezis T, Farnsworth R, Harris N, Williams S, Caesar C, Byrne D, et al.
Cancer Res
. 2019 Feb;
79(7):1558-1572.
PMID: 30709930
Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymphangiogenesis), or remodeling of existing lymphatics, is thought to facilitate the entry...
9.
Achen M, Stacker S
Trends Cancer
. 2018 Aug;
4(8):519-522.
PMID: 30064660
Even though we have known for over 250 years that cancers spread to regional lymph nodes (LNs) and distant organs, the fundamental question of which anatomical routes are taken by...
10.
Farnsworth R, Achen M, Stacker S
Curr Opin Immunol
. 2018 Apr;
53:64-73.
PMID: 29698919
While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying mechanisms is still evolving. Lymphatic vessels provide a route for...