Manuel Stucki
Overview
Explore the profile of Manuel Stucki including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
2608
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Recent Articles
1.
Torres Esteban M, Stewart M, Bragginton E, Meroni A, Pellizzari A, Jeanrenaud A, et al.
Life Sci Alliance
. 2025 Mar;
8(5).
PMID: 40049731
Ubiquitylation is critically implicated in the recognition and repair of DNA double-strand breaks. The adaptor protein MDC1 mediates the recruitment of the key DNA damage responsive E3 ubiquitin ligase RNF8...
2.
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, et al.
J Clin Invest
. 2024 Aug;
134(16).
PMID: 39145459
No abstract available.
3.
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, et al.
J Clin Invest
. 2023 Oct;
133(23).
PMID: 37824211
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still...
4.
De Marco Zompit M, Torres Esteban M, Mooser C, Adam S, Rossi S, Jeanrenaud A, et al.
Nat Commun
. 2022 Jul;
13(1):4143.
PMID: 35842428
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB...
5.
Adam S, Rossi S, Moatti N, De Marco Zompit M, Xue Y, Ng T, et al.
Nat Cancer
. 2022 Feb;
2(12):1357-1371.
PMID: 35121901
BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by...
6.
De Marco Zompit M, Stucki M
DNA Repair (Amst)
. 2021 Aug;
108:103215.
PMID: 34455186
During mitosis, chromosomes undergo extensive structural changes resulting in the formation of compact cylindrical bodies and in the termination of the bulk of DNA-dependent metabolic activities. Therefore, DNA lesions that...
7.
Olcina M, Kim R, Balanis N, Li C, von Eyben R, Graeber T, et al.
iScience
. 2020 Nov;
23(10):101594.
PMID: 33205012
The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood,...
8.
Blackford A, Stucki M
Trends Biochem Sci
. 2020 Feb;
45(4):321-331.
PMID: 32001093
DNA double-strand breaks (DSBs) are highly toxic lesions that can lead to chromosomal instability if they are not repaired correctly. DSBs are especially dangerous in mitosis when cells go through...
9.
Mooser C, Symeonidou I, Leimbacher P, Ribeiro A, Shorrocks A, Jungmichel S, et al.
Nat Commun
. 2020 Jan;
11(1):123.
PMID: 31913317
Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events...
10.
Samartzis E, Fink D, Stucki M, Imesch P
Reprod Biol Endocrinol
. 2019 Apr;
17(1):38.
PMID: 30981279
Background: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent...