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Andrew N Blackford

Explore the profile of Andrew N Blackford including associated specialties, affiliations and a list of published articles. Areas
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Articles 34
Citations 2533
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Recent Articles
1.
Wijnhoven P, Konietzny R, Blackford A, Travers J, Kessler B, Nishi R, et al.
Mol Cell . 2025 Jan; 85(3):665. PMID: 39818214
No abstract available.
2.
Tsukada K, Jones S, Bannister J, Durin M, Vendrell I, Fawkes M, et al.
Mol Cell . 2024 Jan; 84(4):640-658.e10. PMID: 38266639
The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA replication intermediates to promote sister...
3.
Groelly F, Fawkes M, Dagg R, Blackford A, Tarsounas M
Nat Rev Cancer . 2022 Dec; 23(2):78-94. PMID: 36471053
Cells have evolved a complex network of biochemical pathways, collectively known as the DNA damage response (DDR), to prevent detrimental mutations from being passed on to their progeny. The DDR...
4.
Groelly F, Dagg R, Petropoulos M, Rossetti G, Prasad B, Panagopoulos A, et al.
Mol Cell . 2022 Aug; 82(18):3382-3397.e7. PMID: 36002001
Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we identify genome-wide the sites where...
5.
De Marco Zompit M, Torres Esteban M, Mooser C, Adam S, Rossi S, Jeanrenaud A, et al.
Nat Commun . 2022 Jul; 13(1):4143. PMID: 35842428
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB...
6.
Hodson C, Low J, van Twest S, Jones S, Swuec P, Murphy V, et al.
Proc Natl Acad Sci U S A . 2022 Feb; 119(6). PMID: 35115399
The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome complex") for dissolution of double Holliday junctions, key intermediates in homologous recombination....
7.
Shorrocks A, Jones S, Tsukada K, Morrow C, Belblidia Z, Shen J, et al.
Nat Commun . 2021 Jan; 12(1):585. PMID: 33500419
The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover homologous recombination (HR) products....
8.
Henssen A, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, et al.
Nat Genet . 2020 Sep; 52(11):1265. PMID: 32918070
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Ochi T, Quarantotti V, Lin H, Jullien J, E Silva I, Boselli F, et al.
Structure . 2020 May; 28(6):674-689.e11. PMID: 32375023
Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated structures, such...
10.
Blackford A, Stucki M
Trends Biochem Sci . 2020 Feb; 45(4):321-331. PMID: 32001093
DNA double-strand breaks (DSBs) are highly toxic lesions that can lead to chromosomal instability if they are not repaired correctly. DSBs are especially dangerous in mitosis when cells go through...