Claudia Lukas
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Explore the profile of Claudia Lukas including associated specialties, affiliations and a list of published articles.
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44
Citations
9080
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Recent Articles
1.
Mund A, Coscia F, Kriston A, Hollandi R, Kovacs F, Brunner A, et al.
Nat Biotechnol
. 2022 May;
40(8):1231-1240.
PMID: 35590073
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here, we introduce Deep Visual Proteomics (DVP), which...
2.
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al.
Genome Biol
. 2022 Apr;
23(1):107.
PMID: 35484586
No abstract available.
3.
Hendriks I, Buch-Larsen S, Prokhorova E, Elsborg J, Rebak A, Zhu K, et al.
Nat Commun
. 2021 Oct;
12(1):5893.
PMID: 34625544
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted...
4.
Ochs F, Karemore G, Miron E, Brown J, Sedlackova H, Rask M, et al.
Nature
. 2019 Oct;
574(7779):571-574.
PMID: 31645724
To safeguard genome integrity in response to DNA double-strand breaks (DSBs), mammalian cells mobilize the neighbouring chromatin to shield DNA ends against excessive resection that could undermine repair fidelity and...
5.
Spies J, Lukas C, Somyajit K, Rask M, Lukas J, Neelsen K
Nat Cell Biol
. 2019 Feb;
21(4):487-497.
PMID: 30804506
Failure to complete DNA replication is a stochastic by-product of genome doubling in almost every cell cycle. During mitosis, under-replicated DNA (UR-DNA) is converted into DNA lesions, which are inherited...
6.
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al.
Genome Biol
. 2018 Mar;
19(1):37.
PMID: 29548335
Background: Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected...
7.
Sotiriou S, Kamileri I, Lugli N, Evangelou K, Da-Re C, Huber F, et al.
Mol Cell
. 2016 Dec;
64(6):1127-1134.
PMID: 27984746
Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To...
8.
S Pedersen R, Karemore G, Gudjonsson T, Rask M, Neumann B, Heriche J, et al.
Nat Commun
. 2016 Dec;
7:13887.
PMID: 27976684
Genome integrity relies on precise coordination between DNA replication and chromosome segregation. Whereas replication stress attracted much attention, the consequences of mitotic perturbations for genome integrity are less understood. Here,...
9.
Ochs F, Somyajit K, Altmeyer M, Rask M, Lukas J, Lukas C
Nat Struct Mol Biol
. 2016 Jun;
23(8):714-21.
PMID: 27348077
Repair of DNA double-strand breaks (DSBs) in mammals is coordinated by the ubiquitin-dependent accumulation of 53BP1 at DSB-flanking chromatin. Owing to its ability to limit DNA-end processing, 53BP1 is thought...
10.
Zong D, Callen E, Pegoraro G, Lukas C, Lukas J, Nussenzweig A
Nucleic Acids Res
. 2015 Apr;
43(10):4950-61.
PMID: 25916843
DNA double strand breaks (DSBs) formed during S phase are preferentially repaired by homologous recombination (HR), whereas G1 DSBs, such as those occurring during immunoglobulin class switch recombination (CSR), are...