Manolis Kellis
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Explore the profile of Manolis Kellis including associated specialties, affiliations and a list of published articles.
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309
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58937
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Recent Articles
11.
Loughran G, De Pace R, Ding N, Zhang J, Jungreis I, Carancini G, et al.
bioRxiv
. 2024 Oct;
PMID: 39372779
Programmed ribosomal frameshifting is a process where a proportion of ribosomes change their reading frame on an mRNA, rephasing the ribosome relative to the mRNA. While frameshifting is commonly employed...
12.
Sumida T, Lincoln M, He L, Park Y, Ota M, Oguchi A, et al.
Sci Transl Med
. 2024 Aug;
16(762):eadp1720.
PMID: 39196959
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4FOXP3 regulatory T cells (T) play a central role in preventing autoimmunity,...
13.
Yoo D, Rhie A, Hebbar P, Antonacci F, Logsdon G, Solar S, et al.
bioRxiv
. 2024 Aug;
PMID: 39131277
We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy...
14.
Pacheco M, Gerard D, Mangan R, Chapman A, Hecker D, Kellis M, et al.
bioRxiv
. 2024 Aug;
PMID: 39091778
Background: Constraint-based network modeling is a powerful genomic-scale approach for analyzing cellular metabolism, capturing metabolic variations across tissues and cell types, and defining the metabolic identity essential for identifying disease-associated...
15.
Mathys H, Boix C, Akay L, Xia Z, Davila-Velderrain J, Ng A, et al.
Nature
. 2024 Jul;
632(8026):858-868.
PMID: 39048816
Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways that underlie its pathological progression across brain regions remain poorly understood. Here we report a single-cell transcriptomic...
16.
Debette S, Caro I, Western D, Namba S, Sun N, Kawaguchi S, et al.
Res Sq
. 2024 Jul;
PMID: 39011113
Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific mechanism-based treatment. We used Mendelian randomization to combine a unique cerebrospinal fluid (CSF) and...
17.
Li C, Chen K, Fang Q, Shi S, Nan J, He J, et al.
Cell Genom
. 2024 Jul;
4(8):100605.
PMID: 38981476
Crosstalk between N-methyladenosine (mA) and epigenomes is crucial for gene regulation, but its regulatory directionality and disease significance remain unclear. Here, we utilize quantitative trait loci (QTLs) as genetic instruments...
18.
von Maydell D, Wright S, Bonner J, Staab C, Spitaleri A, Liu L, et al.
bioRxiv
. 2024 Jul;
PMID: 38979214
Loss-of-function (LoF) variants in the lipid transporter ABCA7 significantly increase the risk of Alzheimer's disease (odds ratio ∼2), yet the pathogenic mechanisms and the neural cell types affected by these...
19.
Schmauch E, Severin Y, Xing X, Mangold A, Conrad C, Johannsen P, et al.
Sci Adv
. 2024 Jul;
10(27):eado2365.
PMID: 38959302
Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease with a poorly understood pathogenesis. Through a molecularly driven precision medicine approach and an extensive mechanistic pathway analysis in PRP...
20.
Velez-Arce A, Li M, Gao W, Lin X, Huang K, Fu T, et al.
bioRxiv
. 2024 Jul;
PMID: 38948789
Drug discovery AI datasets and benchmarks have not traditionally included single-cell analysis biomarkers. While benchmarking efforts in single-cell analysis have recently released collections of single-cell tasks, they have yet to...