Manolis Kellis
Overview
Explore the profile of Manolis Kellis including associated specialties, affiliations and a list of published articles.
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309
Citations
58937
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Recent Articles
21.
Whited A, Jungreis I, Allen J, Cleveland C, Mudge J, Kellis M, et al.
Biophys Rep (N Y)
. 2024 Jun;
4(3):100167.
PMID: 38909903
Significant efforts have been made to characterize the biophysical properties of proteins. Small proteins have received less attention because their annotation has historically been less reliable. However, recent improvements in...
22.
Ament S, Campbell R, Lobo M, Receveur J, Agrawal K, Borjabad A, et al.
Mol Psychiatry
. 2024 Jun;
29(12):3950-3961.
PMID: 38879719
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One...
23.
Ohta R, Tanigawa Y, Suzuki Y, Kellis M, Morishita S
Nat Commun
. 2024 May;
15(1):4433.
PMID: 38811555
Dominance heritability in complex traits has received increasing recognition. However, most polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present GenoBoost, a flexible PGS modeling framework capable...
24.
Ruzicka W, Mohammadi S, Fullard J, Davila-Velderrain J, Subburaju S, Tso D, et al.
Science
. 2024 May;
384(6698):eadg5136.
PMID: 38781388
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed single-cell dissection of schizophrenia-associated transcriptomic changes in the human prefrontal...
25.
Linna-Kuosmanen S, Schmauch E, Galani K, Ojanen J, Boix C, Ord T, et al.
Cell Rep Med
. 2024 May;
5(5):101556.
PMID: 38776872
Cardiovascular disease plays a central role in the electrical and structural remodeling of the right atrium, predisposing to arrhythmias, heart failure, and sudden death. Here, we dissect with single-nuclei RNA...
26.
Schmauch E, Piening B, Mohebnasab M, Xia B, Zhu C, Stern J, et al.
Nat Med
. 2024 May;
30(5):1448-1460.
PMID: 38760586
In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed...
27.
Garcia-Montojo M, Fathi S, Rastegar C, Simula E, Doucet-OHare T, Cheng Y, et al.
Nat Commun
. 2024 May;
15(1):4163.
PMID: 38755145
TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive. Asparaginase-like-1 protein (ASRGL1) cleaves isoaspartates, which alter protein...
28.
Babu S, Chen J, Robitschek E, Baron C, McConnell A, Wu C, et al.
bioRxiv
. 2024 May;
PMID: 38712250
Mucosal melanoma (MM) is a deadly cancer derived from mucosal melanocytes. To test the consequences of MM genetics, we developed a zebrafish model in which all melanocytes experienced CCND1 expression...
29.
Lee J, Yun S, Kim Y, Chen T, Kellis M, Park C
Brief Bioinform
. 2024 May;
25(3).
PMID: 38706317
Single-cell RNA sequencing (scRNA-seq) enables the exploration of cellular heterogeneity by analyzing gene expression profiles in complex tissues. However, scRNA-seq data often suffer from technical noise, dropout events and sparsity,...
30.
Whited A, Jungreis I, Allen J, Cleveland C, Mudge J, Kellis M, et al.
bioRxiv
. 2024 Apr;
PMID: 38659920
Significant efforts have been made to characterize the biophysical properties of proteins. Small proteins have received less attention because their annotation has historically been less reliable. However, recent improvements in...