Manoja K Brahma
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Explore the profile of Manoja K Brahma including associated specialties, affiliations and a list of published articles.
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24
Citations
438
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Recent Articles
11.
Brewer R, Collins H, Berry R, Brahma M, Tirado B, Peliciari-Garcia R, et al.
Life Sci
. 2018 Feb;
197:30-39.
PMID: 29410090
Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be...
12.
Wende A, Brahma M, McGinnis G, Young M
JACC Basic Transl Sci
. 2017 Sep;
2(3):297-310.
PMID: 28944310
For more than half a century, metabolic perturbations have been explored in the failing myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by depressed fatty acid oxidation...
13.
Wende A, Kim J, Holland W, Wayment B, ONeill B, Tuinei J, et al.
Am J Physiol Heart Circ Physiol
. 2017 Aug;
313(6):H1098-H1108.
PMID: 28822962
Pathological cardiac hypertrophy may be associated with reduced expression of glucose transporter 4 (GLUT4) in contrast to exercise-induced cardiac hypertrophy, where GLUT4 levels are increased. However, mice with cardiac-specific deletion...
14.
McGinnis G, Tang Y, Brewer R, Brahma M, Stanley H, Shanmugam G, et al.
J Mol Cell Cardiol
. 2017 Jul;
110:80-95.
PMID: 28736261
Cardiovascular physiology exhibits time-of-day-dependent oscillations, which are mediated by both extrinsic (e.g., environment/behavior) and intrinsic (e.g., circadian clock) factors. Disruption of circadian rhythms negatively affects multiple cardiometabolic parameters. Recent studies...
15.
Brahma M, Pepin M, Wende A
Diabetes Metab J
. 2017 Feb;
41(1):1-9.
PMID: 28236380
Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level...
16.
Brahma M, Adam R, Pollak N, Jaeger D, Zierler K, Pocher N, et al.
J Lipid Res
. 2014 Sep;
55(11):2229-41.
PMID: 25176985
Fibroblast growth factor 21 (FGF21) is a PPARα-regulated gene elucidated in the liver of PPARα-deficient mice or PPARα agonist-treated mice. Mice globally lacking adipose triglyceride lipase (ATGL) exhibit a marked...
17.
Kadam K, Jadhav R, Kandre S, Guha T, Reddy M, Brahma M, et al.
Eur J Med Chem
. 2013 Jun;
65:337-47.
PMID: 23735282
Biphenyl carboxylic acids, exemplified by compound 5, are known potent inhibitors of diacylglycerol acyltransferase, DGAT1, an enzyme involved in the final committed step of triglyceride biosynthesis. We have synthesized and...
18.
Khanna S, Burudkar S, Bajaj K, Shah P, Keche A, Ghosh U, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7543-6.
PMID: 23122864
Structure-activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition. A 470-fold improvement in in vitro IC(50)...
19.
Jadhav R, Kadam K, Kandre S, Guha T, Reddy M, Brahma M, et al.
Eur J Med Chem
. 2012 Jun;
54:324-42.
PMID: 22683241
Diacylglycerol acyltransferase, DGAT1, is a promising target enzyme for obesity due to its involvement in the committed step of triglyceride biosynthesis. Amino biphenyl carboxylic acids, exemplified by compound 4, are...
20.
B-Rao C, Kulkarni-Almeida A, Katkar K, Khanna S, Ghosh U, Keche A, et al.
Bioorg Med Chem
. 2012 Apr;
20(9):2930-9.
PMID: 22483591
In recent years, xanthine oxidase has emerged as an important target not only for gout but also for cardiovascular and metabolic disorders involving hyperuricemia. Contrary to popular belief, recent clinical...