Martin E Young
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Explore the profile of Martin E Young including associated specialties, affiliations and a list of published articles.
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178
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6303
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Recent Articles
1.
Islam M, Rawnsley D, Ma X, Navid W, Zhao C, Guan X, et al.
J Clin Invest
. 2025 Feb;
PMID: 39932799
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart failure syndromes remains mechanistically unexamined. We observed...
2.
Ren G, Bhatnagar S, Young M, Lee T, Kim J
Mol Metab
. 2025 Jan;
93:102099.
PMID: 39832563
Objective: Obesity-associated metabolic dysfunction is a major public health concern worldwide. Endothelial dysfunction is a hallmark of metabolic dysfunction, and endothelial cells affect metabolic functions. Because autophagy-related gene 7 (ATG7)...
3.
Bell M, Kane M, Ouyang X, Young M, Jegga A, Chatham J, et al.
J Neurochem
. 2025 Jan;
169(1):e16302.
PMID: 39823370
Enhancing protein O-GlcNAcylation by pharmacological inhibition of the enzyme O-GlcNAcase (OGA) has been considered as a strategy to decrease tau and amyloid-beta phosphorylation, aggregation, and pathology in Alzheimer's disease (AD)....
4.
Bell M, Kane M, Ouyang X, Young M, Jegga A, Chatham J, et al.
bioRxiv
. 2024 Sep;
PMID: 39345543
Abstract Figure:
5.
Kramer J, Chatham J, Young M, Darley-Usmar V, Zhang J
bioRxiv
. 2024 Sep;
PMID: 39345468
-GlcNAcylation is a dynamic and reversible protein post-translational modification of serine or threonine residues which modulates the activity of transcriptional and signaling pathways and controls cellular responses to metabolic and...
6.
Islam M, Rawnsley D, Ma X, Navid W, Zhao C, Foroughi L, et al.
bioRxiv
. 2024 Sep;
PMID: 39282298
Protein aggregates are emerging therapeutic targets in rare monogenic causes of cardiomyopathy and amyloid heart disease, but their role in more prevalent heart failure syndromes remains mechanistically unexamined. We observed...
7.
Mergenthaler P, Balami J, Neuhaus A, Mottahedin A, Albers G, Rothwell P, et al.
Circ Res
. 2024 Mar;
134(6):770-790.
PMID: 38484031
Time-of-day significantly influences the severity and incidence of stroke. Evidence has emerged not only for circadian governance over stroke risk factors, but also for important determinants of clinical outcome. In...
8.
Lal H, Verma S, Wang Y, Xie M, Young M
Circ Res
. 2024 Mar;
134(6):635-658.
PMID: 38484029
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional...
9.
Festus I, Spilberg J, Young M, Cain S, Khoshnevis S, Smolensky M, et al.
Trends Endocrinol Metab
. 2024 Mar;
35(7):607-623.
PMID: 38458859
Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or...
10.
Young M
JACC Basic Transl Sci
. 2024 Jan;
8(12):1613-1628.
PMID: 38205356
Virtually all aspects of physiology fluctuate with respect to the time of day. This is beautifully exemplified by cardiovascular physiology, for which blood pressure and electrophysiology exhibit robust diurnal oscillations....