Manfred Gothert
Overview
Explore the profile of Manfred Gothert including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
545
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0
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Recent Articles
1.
Baranowska-Kuczko M, Kozlowska H, Schlicker E, Gothert M, MacLean M, Kozlowski M, et al.
Pharmacol Rep
. 2020 Apr;
72(3):756-762.
PMID: 32333296
Background: LY393558 is a combined antagonist of serotonin (5-HT) 5-HT receptors and inhibitor of serotonin transporter (SERT). LY393558 reduces 5-HT-induced vasoconstriction and remodelling of rat and/or mouse pulmonary arteries. The...
2.
Gothert M, Bonisch H, Malinowska B, Schlicker E
Pharmacol Rep
. 2020 Feb;
72(2):271-284.
PMID: 32048263
About 40% of the papers within the scientific oeuvre of Manfred Göthert (1939-2019) were dedicated to serotonin (5-hydroxytryptamine, 5-HT). He was not only the witness of the gradual definition of...
3.
Gothert M
Pharmacol Rep
. 2013 Oct;
65(4):771-86.
PMID: 24145072
This review contains background information on the serotonin system, furthermore the suggestion to introduce the term Contemporary Witness Report (CWR) for a novel type of review and, as the main...
4.
Walstab J, Steinhagen F, Bruss M, Gothert M, Bonisch H
Pharmacol Rep
. 2011 Mar;
63(1):45-53.
PMID: 21441610
The aim of this study was to analyze functional properties of the naturally occurring C23S variant of the human 5-HT2C receptor. In HEK293 cells transiently expressing the unedited forms of...
5.
Combrink S, Kostanian A, Walstab J, Barann M, Bruss M, Gothert M, et al.
Pharmacol Rep
. 2009 Nov;
61(5):785-97.
PMID: 19904001
The present study aimed at examining the function and pharmacological properties of the naturally occurring Arg344His variant of the human 5-HT(3A) receptor, identified in a schizophrenic patient. In intact human...
6.
Haenisch B, Linsel K, Bruss M, Gilsbach R, Propping P, Nothen M, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2008 Dec;
150B(7):1013-6.
PMID: 19105200
Dysregulations of central noradrenergic and serotonergic neurotransmission have been suggested to contribute to the pathogenesis of neuropsychiatric disorders such as depression. The norepinephrine transporter (NET; SLC6A2) and the serotonin (5-HT)(1A)...
7.
Haenisch B, von Kugelgen I, Bonisch H, Gothert M, Sauerbruch T, Schepke M, et al.
Am J Physiol Gastrointest Liver Physiol
. 2008 Oct;
295(5):G1104-10.
PMID: 18832451
Regulation of agmatine homeostasis has so far only been poorly defined. In the present study, three mechanisms regulating human agmatine homeostasis were investigated. 1) Enzymatic regulation: expression of arginine decarboxylase,...
8.
Racz I, Bilkei-Gorzo A, Markert A, Stamer F, Gothert M, Zimmer A
Eur J Pharmacol
. 2008 Sep;
596(1-3):98-101.
PMID: 18775693
Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB(1) and CB(2) receptors. These residual effects are thought to result, in part, from...
9.
Baranowska U, Gothert M, Rudz R, Malinowska B
J Pharmacol Exp Ther
. 2008 Jun;
326(3):912-9.
PMID: 18567834
Methanandamide (MAEA), the stable analog of the endocannabinoid anandamide, has been proven in Xenopus oocytes to allosterically inhibit the function of the alpha7-nicotinic acetylcholine receptors (nAChRs) in a cannabinoid (CB)...
10.
Molderings G, Gothert M, von Kugelgen I
Pharmacol Rep
. 2008 Jan;
59(6):789-94.
PMID: 18195472
The present study aimed at investigating the influence of imidazoline receptor ligands on the proliferation of PC12 cells and the involvement of the sphingosine-1-phosphate (S1P) signaling system in this effect....