Ivar von Kugelgen
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Explore the profile of Ivar von Kugelgen including associated specialties, affiliations and a list of published articles.
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42
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1350
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Recent Articles
1.
von Kugelgen I
Purinergic Signal
. 2023 Sep;
20(2):99-108.
PMID: 37697211
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y, P2Y, P2Y, P2Y, P2Y, P2Y, P2Y, and P2Y). The widely expressed P2Y receptors...
2.
Philippu A, Greim H, Schlicker E, von Kugelgen I
Naunyn Schmiedebergs Arch Pharmacol
. 2022 Jul;
395(9):1125-1137.
PMID: 35790575
Athineos Philippu, Department of Pharmacology and Toxicology, University of Innsbruck, Austria The eighth pharmacologic-historical Forum was held online in 2022 in Bonn during the Meeting of the DGPT. In this...
3.
von Kugelgen I
Biochem Pharmacol
. 2020 Dec;
187:114361.
PMID: 33309519
Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1 and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular adenine and uracil nucleotides. Eight mammalian P2Y receptor...
4.
Jacobson K, Delicado E, Gachet C, Kennedy C, von Kugelgen I, Li B, et al.
Br J Pharmacol
. 2020 Feb;
177(11):2413-2433.
PMID: 32037507
Eight G protein-coupled P2Y receptor subtypes respond to extracellular adenine and uracil mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin-like GPCRs and contain two structurally distinct...
5.
Kose M, Pillaiyar T, Namasivayam V, De Filippo E, Sylvester K, Ulven T, et al.
J Med Chem
. 2019 Nov;
63(5):2391-2410.
PMID: 31721581
The orphan G protein-coupled receptor (GPCR) GPR84 is expressed on immune cells mediating proinflammatory and immunostimulatory effects. In this study, we prepared the fully efficacious, nonbiased GPR84 agonist 6-hexylamino-2,4(1,3)-pyrimidinedione ()...
6.
von Kugelgen I
Brain Res Bull
. 2019 Mar;
151:12-24.
PMID: 30922852
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups (P2Y, P2Y, P2Y, P2Y, and P2Y) and (P2Y, P2Y, and...
7.
Pillaiyar T, Kose M, Namasivayam V, Sylvester K, Borges G, Thimm D, et al.
ACS Omega
. 2018 Jul;
3(3):3365-3383.
PMID: 30023867
GPR84, a G protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer. Recently, 6-octylaminouracil () has been reported to...
8.
Cattaneo M, von Kugelgen I
Circulation
. 2018 May;
137(21):2309.
PMID: 29784689
No abstract available.
9.
von Kugelgen I
Adv Exp Med Biol
. 2017 Sep;
1051:123-138.
PMID: 28921447
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. The platelet ADP-receptor which has been denominated P2Y receptor is an important target in pharmacotherapy. The receptor couples to G mediating...
10.
Pillaiyar T, Kose M, Sylvester K, Weighardt H, Thimm D, Borges G, et al.
J Med Chem
. 2017 Apr;
60(9):3636-3655.
PMID: 28406627
The G protein-coupled receptor GPR84, which is activated by (hydroxy)fatty acids, is highly expressed on immune cells. Recently, 3,3'-diindolylmethane was identified as a heterocyclic, nonlipid-like GPR84 agonist. We synthesized a...