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Heinz Bonisch

Explore the profile of Heinz Bonisch including associated specialties, affiliations and a list of published articles. Areas
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Articles 46
Citations 912
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Recent Articles
1.
Bonisch H
Handb Exp Pharmacol . 2021 Sep; 266:119-167. PMID: 34495395
The gene products of the SLC22A gene family (hOCT1, hOCT2, and hOCT3) and of the SLC29A4 gene (hPMAT or hENT4) are all polyspecific organic cation transporters. Human OCTs (including hPMAT)...
2.
Gothert M, Bonisch H, Malinowska B, Schlicker E
Pharmacol Rep . 2020 Feb; 72(2):271-284. PMID: 32048263
About 40% of the papers within the scientific oeuvre of Manfred Göthert (1939-2019) were dedicated to serotonin (5-hydroxytryptamine, 5-HT). He was not only the witness of the gradual definition of...
3.
Wenge B, Bonisch H
Neurochem Res . 2013 Mar; 38(7):1303-14. PMID: 23525969
The thiol reagent N-ethylmaleimide (NEM) is known to inhibit irreversibly ligand binding by the norepinephrine transporter (NET), while the simultaneous presence of NET substrates or ligands protects from this inhibition....
4.
Haenisch B, Drescher E, Thiemer L, Xin H, Giros B, Gautron S, et al.
Naunyn Schmiedebergs Arch Pharmacol . 2012 Jul; 385(10):1017-23. PMID: 22806583
Besides the three antidepressant-sensitive, Na(+)- and Cl(-)-dependent monoamine transporters, Na(+)-independent organic cation transporters (OCTs) are known to transport monoamines. However, little is known about the interactions of psychotropic drugs with...
5.
Haenisch B, Hiemke C, Bonisch H
Psychopharmacology (Berl) . 2011 Apr; 217(2):289-95. PMID: 21484238
Rationale: The antidepressant trimipramine shows an atypical pharmacological profile and its mechanism of action is still obscure. Objectives: The present study investigated whether trimipramine and three of its metabolites interact...
6.
Haenisch B, Bonisch H
Pharmacogenet Genomics . 2011 Apr; 21(7):432-5. PMID: 21478802
Sumatriptan, an antimigraine drug, causes contraction of human coronary arteries through activation of 5-HT1B receptors which couple to Gi/Go inducing inhibition of adenylate cyclase. At a rare, naturally occurring human...
7.
Walstab J, Steinhagen F, Bruss M, Gothert M, Bonisch H
Pharmacol Rep . 2011 Mar; 63(1):45-53. PMID: 21441610
The aim of this study was to analyze functional properties of the naturally occurring C23S variant of the human 5-HT2C receptor. In HEK293 cells transiently expressing the unedited forms of...
8.
Pick A, Muller H, Mayer R, Haenisch B, Pajeva I, Weigt M, et al.
Bioorg Med Chem . 2011 Mar; 19(6):2090-102. PMID: 21354800
Flavonoids are an interesting group of natural products ubiquitously present in human diet. Their consumption has been associated with various and differing beneficial health effects. However, several flavonoids have been...
9.
Haenisch B, Bonisch H, Cichon S, Allam J, Novak N, Molderings G
Leuk Res . 2011 Jan; 35(9):1248-53. PMID: 21236489
Impairment of agmatine homeostasis is involved in the regulation of cell proliferation in malignant solid tumors. The present study aimed at analyzing the relevance of agmatine homeostasis in pathophysiology of...
10.
Wenge B, Geyer J, Bonisch H
Naunyn Schmiedebergs Arch Pharmacol . 2011 Jan; 383(2):203-8. PMID: 21212936
The muscarinic antagonists oxybutynin and trospium are used as spasmolytic agents for the treatment of overactive urinary bladder disease. Recently, it has been shown that trospium, but not oxybutynin, is...