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Maja S Engelstoft

Explore the profile of Maja S Engelstoft including associated specialties, affiliations and a list of published articles. Areas
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Articles 22
Citations 1239
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Recent Articles
1.
Grunddal K, Tonack S, Egerod K, Thompson J, Petersen N, Engelstoft M, et al.
Mol Metab . 2021 Apr; 51:101231. PMID: 33831593
Objective: GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation aimed to delineate the cellular expression of...
2.
Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, et al.
Mol Metab . 2019 Nov; 29:24-39. PMID: 31668390
Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher...
3.
Jepsen S, Grunddal K, Wewer Albrechtsen N, Engelstoft M, Gabe M, Jensen E, et al.
Am J Physiol Endocrinol Metab . 2019 Sep; 317(6):E1081-E1093. PMID: 31503512
DPP-4 inhibitors, used for treatment of type 2 diabetes, act by increasing the concentrations of intact glucagon-like peptide-1 (GLP-1), but at the same time, they inhibit secretion of GLP-1, perhaps...
4.
Rudenko O, Shang J, Munk A, Ekberg J, Petersen N, Engelstoft M, et al.
Mol Metab . 2018 Nov; 19:49-64. PMID: 30472415
Objectives: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear. Methods...
5.
Jorgensen M, de Lichtenberg K, Collin C, Klinck R, Ekberg J, Engelstoft M, et al.
Development . 2018 Aug; 145(17). PMID: 30093553
Mutations in , a target gene of the Notch signalling pathway, lead to ectopic pancreas by a poorly described mechanism. Here, we use genetic inactivation of combined with lineage tracing...
6.
Lund M, Egerod K, Engelstoft M, Dmytriyeva O, Theodorsson E, Patel B, et al.
Mol Metab . 2018 Mar; 11:70-83. PMID: 29576437
Objectives: 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors...
7.
Frimurer T, Mende F, Graae A, Engelstoft M, Egerod K, Nygaard R, et al.
J Med Chem . 2017 Jan; 60(3):886-898. PMID: 28045522
The G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn. We used a homology model-based approach to identify small-molecule pharmacological tool compounds for the receptor. The method focused...
8.
Ekberg J, Hauge M, Kristensen L, Madsen A, Engelstoft M, Husted A, et al.
Endocrinology . 2016 Oct; 157(12):4561-4569. PMID: 27779915
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G Protein-coupled Receptor [GPR] 40), FFA4 (GPR120), and GPR119, which all recognize TG...
9.
Norn C, Hauge M, Engelstoft M, Kim S, Lehmann J, Jones R, et al.
Structure . 2015 Nov; 23(12):2377-2386. PMID: 26526849
Recent benchmark studies have demonstrated the difficulties in obtaining accurate predictions of ligand binding conformations to comparative models of G-protein-coupled receptors. We have developed a data-driven optimization protocol, which integrates...
10.
Svendsen B, Pais R, Engelstoft M, Milev N, Richards P, Christiansen C, et al.
J Endocrinol . 2015 Oct; 228(1):39-48. PMID: 26483393
The incretin hormones glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from intestinal endocrine cells, the so-called L- and K-cells. The cells are derived from a common precursor...