Stefan Offermanns
Overview
Explore the profile of Stefan Offermanns including associated specialties, affiliations and a list of published articles.
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Articles
288
Citations
16019
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Recent Articles
1.
Kwon J, Kawase H, Mattonet K, Guenther S, Hahnefeld L, Shamsara J, et al.
Nat Commun
. 2025 Feb;
16(1):1448.
PMID: 39920161
Macrophages express numerous G protein-coupled receptors (GPCRs) that regulate adhesion, migration, and activation, but the function of orphan receptor GPRC5B in macrophages is unknown. Both resident peritoneal and bone marrow-derived...
2.
Cho H, Lai C, Bonnavion R, Alnouri M, Wang S, Roquid K, et al.
Science
. 2025 Feb;
387(6734):674-682.
PMID: 39913566
Insulin resistance is a hallmark of obesity-associated type 2 diabetes. Insulin's actions go beyond metabolic cells and also involve blood vessels, where insulin increases capillary blood flow and delivery of...
3.
Szpakowska M, Legler D, Offermanns S, Sozzani S, Rot A, Thelen M, et al.
Nat Rev Immunol
. 2025 Feb;
25(3):225-226.
PMID: 39900975
No abstract available.
4.
Hernandez-Olmos V, Heering J, Ildefeld N, Ehrler J, Kaps A, Rajkumar R, et al.
J Med Chem
. 2025 Jan;
68(2):1195-1221.
PMID: 39803894
The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor, which is endogenously activated by 12()-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT). BLT2 is gaining attention as a potential therapeutic target involved in...
5.
Su M, Zhao W, Jiang H, Zhao Y, Liao Z, Liu Z, et al.
Nat Cardiovasc Res
. 2025 Jan;
4(2):145-162.
PMID: 39794479
Beyond dyslipidemia, inflammation contributes to the development of atherosclerosis. However, intrinsic factors that counteract vascular inflammation and atherosclerosis remain scarce. Here we identify insulin-like growth factor binding protein 6 (IGFBP6)...
6.
Jin Y, Liang G, Li R, Wang S, Alnouri M, Bentsen M, et al.
Nat Cardiovasc Res
. 2025 Jan;
4(2):180-196.
PMID: 39779823
Atherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here...
7.
Yoshida T, Yoshida S, Inukai K, Kato K, Yura Y, Hattori T, et al.
FASEB J
. 2024 Nov;
38(22):e70192.
PMID: 39556326
Protein phosphorylation, controlled by protein kinases, is central to regulating various pathophysiological processes, including cardiac systolic function. The dysregulation of protein kinase activity plays a significant role in the pathogenesis...
8.
Alnouri M, Roquid K, Bonnavion R, Cho H, Heering J, Kwon J, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(41):e2407130121.
PMID: 39365815
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can...
9.
Yoshida S, Yoshida T, Inukai K, Kato K, Yura Y, Hattori T, et al.
Nat Commun
. 2024 Sep;
15(1):7638.
PMID: 39266515
Chronic fibrotic tissue disrupts various organ functions. Despite significant advances in therapies, mortality and morbidity due to heart failure remain high, resulting in poor quality of life. Beyond the cardiomyocyte-centric...
10.
Keshavarz M, Ruppert A, Meiners M, Poharkar K, Liu S, Mahmoud W, et al.
Sci Rep
. 2024 Aug;
14(1):18447.
PMID: 39117690
Disorders of gallbladder motility can lead to serious pathology. Bitter tastants acting upon bitter taste receptors (TAS2R family) have been proposed as a novel class of smooth muscle relaxants to...