Jens J Holst
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Explore the profile of Jens J Holst including associated specialties, affiliations and a list of published articles.
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730
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19097
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Recent Articles
1.
Sorensen K, Justesen J, Angquist L, Bork-Jensen J, Hartmann B, Jorgensen N, et al.
Diabetologia
. 2025 Mar;
PMID: 40064676
Aims/hypothesis: An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prevalence....
2.
Muller T, Adriaenssens A, Ahren B, Bluher M, Birkenfeld A, Birkenfeld A, et al.
Mol Metab
. 2025 Mar;
95:102118.
PMID: 40024571
Background: Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in the maintenance of glucose tolerance in healthy humans. Until recently GIP had not been...
3.
Madsbad S, Holst J
Expert Opin Investig Drugs
. 2025 Mar;
:1-19.
PMID: 40022548
Introduction: GLP-1-based therapies have changed the treatment of overweight/obesity. Liraglutide 3.0 mg daily, the first GLP-1 RA approved for treatment of overweight, induced a weight loss of 6-8%, Semaglutide 2.4 ...
4.
Galsgaard K, Elmelund E, Hunt J, Smits M, Grevengoed T, Christoffersen C, et al.
Physiol Rep
. 2025 Feb;
13(4):e70235.
PMID: 39985139
Glucagon is secreted from the pancreatic alpha cells and regulates not only hepatic glucose production, but also hepatic lipid and amino acid metabolism. Thus, glucagon provides a switch from hepatic...
5.
Anjom-Shoae J, Hajishafiee M, Fitzgerald P, Coleman R, Martin A, Poppitt S, et al.
Am J Clin Nutr
. 2025 Feb;
PMID: 39978467
Background: L-tryptophan ("Trp") and L-leucine ("Leu"), when administered intraduodenally, increase plasma cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) and stimulate pyloric pressures, which all slow gastric emptying and suppress subsequent...
6.
Galsgaard K, Vergara J, Jepsen S, Bazzichi A, Kissow H, Smits M, et al.
Am J Physiol Endocrinol Metab
. 2025 Feb;
328(3):E435-E446.
PMID: 39933706
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones. Lack of GLP-1 receptor signaling has been reported to be compensated for by increased GIP secretion and action. Conversely,...
7.
Galsgaard K, Modvig I, Holst J
Biochem Soc Trans
. 2025 Jan;
53(1).
PMID: 39887325
In the gastrointestinal (GI) tract, food is digested and absorbed while GI hormones are secreted from the enteroendocrine cells (EECs). These hormones regulate food intake, glucose homeostasis, digestion, GI motility,...
8.
Anjom-Shoae J, Fitzgerald P, Horowitz M, Holst J, Rehfeld J, Veedfald S, et al.
J Clin Endocrinol Metab
. 2025 Jan;
PMID: 39785828
Context: In males of normal weight, intraduodenal administration of calcium enhances the effects of the amino acid, L-tryptophan (Trp), to suppress energy intake, associated with greater stimulation of cholecystokinin (CCK),...
9.
Mezza T, Wewer Albrechtsen N, Giuseppe G, Ferraro P, Soldovieri L, Ciccarelli G, et al.
Metabolism
. 2024 Dec;
163:156087.
PMID: 39626843
Aims: A number of studies have suggested that pancreatic α cells produce intact GLP-1, thereby constituting a gut-independent paracrine incretin system. However, the debate on whether human α cells contain...
10.
Thomsen M, Skytte M, Samkani A, Weber P, Fenger M, Frystyk J, et al.
Am J Clin Nutr
. 2024 Dec;
121(2):224-231.
PMID: 39617302
Background: Dyslipidemia with elevated concentrations of triacylglycerol-rich lipoproteins (TRLs), small-dense LDL, and reduced HDL is linked to hepatic steatosis and promotes atherogenesis in type 2 diabetes (T2D). Objectives: We aimed...