Mahesh Ramamoorthy
Overview
Explore the profile of Mahesh Ramamoorthy including associated specialties, affiliations and a list of published articles.
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21
Citations
605
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Recent Articles
1.
Prabahar A, Zamora R, Barclay D, Yin J, Ramamoorthy M, Bagheri A, et al.
NAR Genom Bioinform
. 2024 Feb;
6(1):lqae019.
PMID: 38344273
The correlation between messenger RNA (mRNA) and protein abundances has long been debated. RNA sequencing (RNA-seq), a high-throughput, commonly used method for analyzing transcriptional dynamics, leaves questions about whether we...
2.
Dejosez M, DallAgnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, et al.
Cell Rep
. 2023 May;
42(5):112505.
PMID: 37182209
Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes...
3.
Elagooz R, Dhara A, Gott R, Adams S, White R, Ghosh A, et al.
Blood Adv
. 2022 Jun;
6(23):6016-6022.
PMID: 35667093
The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle...
4.
Leitner D, Ramamoorthy M, Dejosez M, Zwaka T
Stem Cell Res
. 2019 Nov;
41:101617.
PMID: 31731178
Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway. However, this approach...
5.
Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau D, Bohr V
Nucleic Acids Res
. 2017 Feb;
45(3):1566.
PMID: 28180303
Humans have five RecQ helicases, whereas simpler organisms have only one. Little is known about whether and how these RecQ helicases co-operate and/or complement each other in response to cellular...
6.
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells
Ramamoorthy M, Smith S
Cancer Cell
. 2015 Sep;
28(3):357-69.
PMID: 26373281
The chromatin-remodeler ATRX is frequently lost in cancer cells that use ALT (alternative lengthening of telomeres) for telomere maintenance, but its function in telomere recombination is unknown. Here we show...
7.
Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman M, Croteau D, et al.
Carcinogenesis
. 2013 May;
34(10):2218-30.
PMID: 23715498
Interstrand cross-links (ICLs) are very severe lesions as they are absolute blocks of replication and transcription. This property of interstrand cross-linking agents has been exploited clinically for the treatment of...
8.
Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau D, Bohr V
Nucleic Acids Res
. 2012 Nov;
41(2):881-99.
PMID: 23180761
Humans have five RecQ helicases, whereas simpler organisms have only one. Little is known about whether and how these RecQ helicases co-operate and/or complement each other in response to cellular...
9.
Ramamoorthy M, Vaughan C, Deb S, Palit Deb S
Methods Mol Biol
. 2012 Nov;
962:127-33.
PMID: 23150442
Chemoresistance and increased growth rate are two gain-of-function functions that mutant p53 is thought to possess. Here, we describe two methods for measuring the sensitiveness of cells to chemotherapeutic drugs...
10.
Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, et al.
Mol Biol Cell
. 2012 Sep;
23(21):4273-85.
PMID: 22973052
Human RECQL5 is a member of the RecQ helicase family, which maintains genome stability via participation in many DNA metabolic processes, including DNA repair. Human cells lacking RECQL5 display chromosomal...