Mahesh Ramamoorthy
Overview
Explore the profile of Mahesh Ramamoorthy including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
605
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Ramamoorthy M, Sykora P, Scheibye-Knudsen M, Dunn C, Kasmer C, Zhang Y, et al.
Free Radic Biol Med
. 2012 Aug;
53(6):1371-80.
PMID: 22885031
Alzheimer disease (AD) is a major health problem in the United States, affecting one in eight Americans over the age of 65. The number of elderly suffering from AD is...
12.
Vaughan C, Mohanraj L, Singh S, Dumur C, Ramamoorthy M, Garrett C, et al.
Genes Cancer
. 2012 Jun;
2(10):943-55.
PMID: 22701761
The current model predicts that MDM2 is primarily overexpressed in cancers with wild-type (WT) p53 and contributes to oncogenesis by degrading p53. Following a correlated expression of MDM2 and NF-κB2...
13.
Popuri V, Ramamoorthy M, Tadokoro T, Singh D, Karmakar P, Croteau D, et al.
DNA Repair (Amst)
. 2012 May;
11(7):624-35.
PMID: 22633600
RECQL5 is one of the five human RecQ helicases, involved in the maintenance of genomic integrity. While much insight has been gained into the function of the Werner (WRN) and...
14.
Singh D, Popuri V, Kulikowicz T, Shevelev I, Ghosh A, Ramamoorthy M, et al.
Nucleic Acids Res
. 2012 May;
40(14):6632-48.
PMID: 22544709
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4,...
15.
Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin P, Minor R, et al.
J Exp Med
. 2012 Apr;
209(4):855-69.
PMID: 22473955
Cockayne syndrome (CS) is a devastating autosomal recessive disease characterized by neurodegeneration, cachexia, and accelerated aging. 80% of the cases are caused by mutations in the CS complementation group B...
16.
Croteau D, Rossi M, Canugovi C, Tian J, Sykora P, Ramamoorthy M, et al.
Aging Cell
. 2012 Feb;
11(3):456-66.
PMID: 22296597
RECQL4 is associated with Rothmund-Thomson Syndrome (RTS), a rare autosomal recessive disorder characterized by premature aging, genomic instability, and cancer predisposition. RECQL4 is a member of the RecQ helicase family,...
17.
Yeudall W, Vaughan C, Miyazaki H, Ramamoorthy M, Choi M, Chapman C, et al.
Carcinogenesis
. 2011 Nov;
33(2):442-51.
PMID: 22114072
The role of dominant transforming p53 in carcinogenesis is poorly understood. Our previous data suggested that aberrant p53 proteins can enhance tumorigenesis and metastasis. Here, we examined potential mechanisms through...
18.
Ghosh A, Rossi M, Singh D, Dunn C, Ramamoorthy M, Croteau D, et al.
J Biol Chem
. 2011 Nov;
287(1):196-209.
PMID: 22039056
Telomeres are structures at the ends of chromosomes and are composed of long tracks of short tandem repeat DNA sequences bound by a unique set of proteins (shelterin). Telomeric DNA...
19.
Ramamoorthy M, Tadokoro T, Rybanska I, Ghosh A, Wersto R, May A, et al.
Nucleic Acids Res
. 2011 Oct;
40(4):1621-35.
PMID: 22013166
DNA decatenation mediated by Topoisomerase II is required to separate the interlinked sister chromatids post-replication. SGS1, a yeast homolog of the human RecQ family of helicases interacts with Topoisomerase II...
20.
Frum R, Ramamoorthy M, Mohanraj L, Deb S, Palit Deb S
Mol Cancer Res
. 2009 Aug;
7(8):1253-67.
PMID: 19671680
Overexpression of MDM2 has been related to oncogenesis. In this communication, we present evidence to show that MDM2 controls the cell cycle-dependent expression of cyclin A by using a pathway...