Mahesh Hegde
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Explore the profile of Mahesh Hegde including associated specialties, affiliations and a list of published articles.
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21
Citations
577
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Recent Articles
11.
Hegde M, Mantelingu K, Pandey M, Pavankumar C, Rangappa K, Raghavan S
Target Oncol
. 2016 May;
11(5):655-665.
PMID: 27188390
Background: Cancer is a multifactorial disease, which makes it difficult to cure. Since more than one defective cellular component is often involved during oncogenesis, combination therapy is gaining prominence in...
12.
Srivastava S, Somasagara R, Hegde M, Nishana M, Tadi S, Srivastava M, et al.
Sci Rep
. 2016 Apr;
6:24049.
PMID: 27068577
Naturally occurring compounds are considered as attractive candidates for cancer treatment and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly seen in several fruits and vegetables. In the...
13.
Jagadish S, Rajeev N, NaveenKumar S, Sharath Kumar K, Paul M, Hegde M, et al.
Mol Cell Biochem
. 2016 Feb;
414(1-2):137-51.
PMID: 26899710
Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet destruction severely affects the normal functioning of thrombosis and hemostasis. In addition, frequent...
14.
Sharath Kumar K, Hanumappa A, Vetrivel M, Hegde M, Girish Y, Byregowda T, et al.
Bioorg Med Chem Lett
. 2015 Jul;
25(17):3616-20.
PMID: 26152430
4-Thiazolidinone derivatives were synthesized using T3P®-DMSO media as a cyclodehydrating agent. All the molecules were tested for their cytotoxicity against leukemic cell lines. The compound 3-(4-bromophenyl)-2-(4-(dimethylamino)phenyl)thiazolidin-4-one (4e) with electron donating...
15.
Kumar S, Gopalakrishnan V, Hegde M, Rana V, Dhepe S, Ramareddy S, et al.
Bioorg Med Chem Lett
. 2014 Sep;
24(19):4682-4688.
PMID: 25205189
A series of 2,5,6-substituted imidazo[2,1-b][1,3,4]thiadiazole derivatives have been prepared and were tested for antiproliferative activity on cancer cells at the National Cancer Institute. Results showed that molecules with a benzyl...
16.
Srivastava M, Hegde M, Chiruvella K, Koroth J, Bhattacharya S, Choudhary B, et al.
Sci Rep
. 2014 Aug;
4:6147.
PMID: 25142835
Intake of fruits rich in antioxidants in daily diet is suggested to be cancer preventive. Sapota is a tropical fruit grown and consumed extensively in several countries including India and...
17.
Kumar S, Hegde M, Gopalakrishnan V, Renuka V, Ramareddy S, De Clercq E, et al.
Eur J Med Chem
. 2014 Jul;
84:687-97.
PMID: 25064346
The cytotoxic activity of a new series of 2-(4'-chlorobenzyl)-5,6-disubstituted imidazo[2,1-b][1,3,4]thiadiazoles against different human and murine cancer cell lines is reported. Among the tested compounds, two derivatives namely 2-(4-chlorobenzyl)-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde 4i and...
18.
Sharath Kumar K, Hanumappa A, Hegde M, Narasimhamurthy K, Raghavan S, Rangappa K
Eur J Med Chem
. 2014 May;
81:341-9.
PMID: 24852281
The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The chemical structures of newly synthesized compounds were...
19.
Srivastava M, Nambiar M, Sharma S, Karki S, Goldsmith G, Hegde M, et al.
Cell
. 2012 Dec;
151(7):1474-87.
PMID: 23260137
DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs, thereby serving as a strategy toward...
20.
Somasagara R, Hegde M, Chiruvella K, Musini A, Choudhary B, Raghavan S
PLoS One
. 2012 Oct;
7(10):e47021.
PMID: 23071702
Background: The consumption of berry fruits, including strawberries, has been suggested to have beneficial effects against oxidative stress mediated diseases. Berries contain multiple phenolic compounds and secondary metabolites that contribute...