Mrinal Srivastava
Overview
Explore the profile of Mrinal Srivastava including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
1028
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Recent Articles
1.
Huang M, Yang C, Nie L, Zhang H, Zhu D, Wang C, et al.
Nucleic Acids Res
. 2025 Jan;
53(1).
PMID: 39778868
Cell cycle checkpoints are the regulatory mechanisms that secure the strict order of cellular events for cell division that ensure genome integrity. It has been proposed that mitosis initiation depends...
2.
Zhang H, Xiong Y, Sun Y, Park J, Su D, Feng X, et al.
Sci Adv
. 2023 Dec;
9(49):eadi6681.
PMID: 38055811
Type II topoisomerases (TOP2) form transient TOP2 cleavage complexes (TOP2ccs) during their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA intermediates that are reversible but can be...
3.
Zhang H, Xiong Y, Su D, Wang C, Srivastava M, Tang M, et al.
Nat Commun
. 2022 Jul;
13(1):4240.
PMID: 35869071
Anticancer drugs, such as camptothecin (CPT), trap topoisomerase I (TOP1) on DNA and form TOP1 cleavage complexes (TOP1cc). Alternative repair pathways have been suggested in the repair of TOP1cc. However,...
4.
Kathjoo M, Srivastava M
FEBS J
. 2022 Feb;
289(11):3093-3096.
PMID: 35212156
In response to double-strand breaks (DSBs) in the DNA, cells undergo transcriptional, translational and post-translational reprogramming to tackle the damage. In this study by Riepe et al., the authors have...
5.
Kumari R, Roy U, Desai S, Nilavar N, Van Nieuwenhuijze A, Paranjape A, et al.
Cell Rep
. 2021 Jul;
36(2):109390.
PMID: 34260911
Recombination activating genes (RAGs), consisting of RAG1 and RAG2, are stringently regulated lymphoid-specific genes, which initiate V(D)J recombination in developing lymphocytes. We report the regulation of RAG1 through a microRNA...
6.
Chen Z, Wang C, Feng X, Nie L, Tang M, Zhang H, et al.
EMBO J
. 2021 Jul;
40(17):e107776.
PMID: 34232536
Host-virus protein-protein interactions play key roles in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We conducted a comprehensive interactome study between the virus and host cells...
7.
Tang M, Pei G, Su D, Wang C, Feng X, Srivastava M, et al.
Nucleic Acids Res
. 2021 Jul;
49(13):7476-7491.
PMID: 34197614
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance...
8.
Gopalakrishnan V, Sharma S, Ray U, Manjunath M, Lakshmanan D, Vartak S, et al.
Mol Carcinog
. 2021 Jun;
60(9):627-643.
PMID: 34192388
Nonhomologous end joining (NHEJ), one of the major DNA double-strand break repair pathways, plays a significant role in cancer cell proliferation and resistance to radio and chemotherapeutic agents. Previously, we...
9.
Sharma S, Srivastava M
FEBS J
. 2021 Apr;
288(15):4503-4506.
PMID: 33811455
Cancer immunotherapy represents a very encouraging mode of treatment for cancer where one's immune system is utilized to eliminate tumor cells. Wayne et al. explore inhibition of DNA damage response...
10.
Wang C, Chen Z, Su D, Tang M, Nie L, Zhang H, et al.
DNA Repair (Amst)
. 2020 Aug;
95:102946.
PMID: 32853826
Ataxia Telangiectasia and Rad3-Related kinase (ATR) is a master regulator of genome maintenance, and participates in DNA replication and various DNA repair pathways. In a genome-wide screen for ATR-dependent fitness...