Mahesh B Chandrasekharan
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Explore the profile of Mahesh B Chandrasekharan including associated specialties, affiliations and a list of published articles.
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42
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1145
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Recent Articles
1.
Wu Y, Manna A, Li L, Handa H, Chandrasekharan M, Tantin D
bioRxiv
. 2024 Nov;
PMID: 39574712
Oct4 is a master regulator of pluripotency. Potential Oct4 interactors have been cataloged extensively but the manner and significance of these interactions are incompletely defined. Like other POU domain proteins,...
2.
Shen Z, Wu Y, Manna A, Yi C, Cairns B, Evason K, et al.
Genes Dev
. 2024 May;
38(7-8):308-321.
PMID: 38719541
The transcription factor Oct4/Pou5f1 is a component of the regulatory circuitry governing pluripotency and is widely used to induce pluripotency from somatic cells. Here we used domain swapping and mutagenesis...
3.
Radmall K, Shukla P, Leng A, Chandrasekharan M
bioRxiv
. 2023 Oct;
PMID: 37873190
Post-translational covalent conjugation of ubiquitin onto proteins or ubiquitination is important in nearly all cellular processes. Steady-state ubiquitination of individual proteins is maintained by two countering enzymatic activities: conjugation of...
4.
Radmall K, Shukla P, Leng A, Chandrasekharan M
Sci Rep
. 2023 Oct;
13(1):16731.
PMID: 37794081
Post-translational covalent conjugation of ubiquitin onto proteins or ubiquitination is important in nearly all cellular processes. Steady-state ubiquitination of individual proteins in vivo is maintained by two countering enzymatic activities:...
5.
Perovanovic J, Wu Y, Abewe H, Shen Z, Hughes E, Gertz J, et al.
Sci Signal
. 2023 Apr;
16(781):eadd5750.
PMID: 37071732
The transition between pluripotent and tissue-specific states is a key aspect of development. Understanding the pathways driving these transitions will facilitate the engineering of properly differentiated cells for experimental and...
6.
Shukla P, Radmall K, Chandrasekharan M
Protein Expr Purif
. 2023 Apr;
207:106270.
PMID: 37059371
Custom polyclonal antibodies raised in rabbits are routinely used in immunoblotting and other protein analysis techniques. Custom rabbit polyclonal antisera are generally purified using immunoaffinity or Protein A-affinity chromatography; however,...
7.
Shen Z, Wu Y, Mana A, Yi C, Cairns B, Evason K, et al.
bioRxiv
. 2023 Mar;
PMID: 36865286
The transcription factor Oct4/Pou5f1 is a component of the regulatory circuitry governing pluripotency and is widely used to induce pluripotency from somatic cells. Here we use domain swapping and mutagenesis...
8.
Shukla P, Bissell J, Kumar S, Pokhrel S, Palani S, Radmall K, et al.
Nucleic Acids Res
. 2023 Jan;
51(5):2117-2136.
PMID: 36715322
The conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes....
9.
Leng A, Radmall K, Shukla P, Chandrasekharan M
Methods Protoc
. 2022 Oct;
5(5).
PMID: 36287046
Studies in and have enhanced our understanding of the regulation and functions of histone H2B monoubiquitination (H2Bub1), a key epigenetic marker with important roles in transcription and other processes. The...
10.
Shukla P, Sinha D, Leng A, Bissell J, Thatipamula S, Ganguly R, et al.
J Biol Chem
. 2022 Sep;
298(11):102524.
PMID: 36162503
Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in transcription, genome maintenance, and proteostasis. The contributions of many conserved secondary structures of Rad6 and its human homologs...