Bradley R Cairns
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Explore the profile of Bradley R Cairns including associated specialties, affiliations and a list of published articles.
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109
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10049
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Recent Articles
1.
Jiang Q, Cui L, Nie X, Cai H, Zhang W, Lu X, et al.
Aging Cell
. 2025 Mar;
:e70032.
PMID: 40051066
Aging disrupts immune regulation, affecting tissue function and increasing vulnerability to various diseases. However, the effects of aging on immune cells within human testes are not well understood. In this...
2.
Yi C, Kitamura Y, Maezawa S, Namekawa S, Cairns B
Nat Struct Mol Biol
. 2025 Mar;
PMID: 40033150
Spermatogonial stem cells balance self-renewal with differentiation and spermatogenesis to ensure continuous sperm production. Here, we identify roles for the transcription factor zinc finger and BTB domain-containing protein 16 (ZBTB16;...
3.
Cui L, Nie X, Guo Y, Ren P, Guo Y, Wang X, et al.
Nat Aging
. 2025 Mar;
PMID: 40033047
Testicular aging is associated with declining reproductive health, but the molecular mechanisms are unclear. Here we generate a dataset of 214,369 single-cell transcriptomes from testicular cells of 35 individuals aged...
4.
Shen Z, Wu Y, Manna A, Yi C, Cairns B, Evason K, et al.
Genes Dev
. 2024 May;
38(7-8):308-321.
PMID: 38719541
The transcription factor Oct4/Pou5f1 is a component of the regulatory circuitry governing pluripotency and is widely used to induce pluripotency from somatic cells. Here we used domain swapping and mutagenesis...
5.
Wamaitha S, Nie X, Pandolfi E, Wang X, Yang Y, Stukenborg J, et al.
Dev Cell
. 2023 Aug;
58(20):2097-2111.e3.
PMID: 37582368
Formation of either an ovary or a testis during human embryonic life is one of the most important sex-specific events leading to the emergence of secondary sexual characteristics and sex...
6.
Grow E, Liu Y, Fan Z, Viotti Perisse I, Patrick T, Regouski M, et al.
bioRxiv
. 2023 Apr;
PMID: 37090641
Reprogramming of the gamete into a developmentally competent embryo identity is a fundamental aspect of preimplantation development. One of the most important processes of this reprogramming is the transcriptional awakening...
7.
Smith C, Grow E, Shadle S, Cairns B
bioRxiv
. 2023 Apr;
PMID: 37034731
The embryonic transcription factor DUX regulates chromatin opening and gene expression in totipotent cleavage-stage mouse embryos, and its expression in embryonic stem cells promotes their conversion to 2-cell embryo-like cells...
8.
9.
Nie X, Munyoki S, Sukhwani M, Schmid N, Missel A, Emery B, et al.
Dev Cell
. 2022 May;
57(9):1160-1176.e5.
PMID: 35504286
Aging men display reduced reproductive health; however, testis aging is poorly understood at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over 44,000 cells from both...
10.
Hickey G, Wike C, Nie X, Guo Y, Tan M, Murphy P, et al.
Elife
. 2022 Jan;
11.
PMID: 34982026
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of...