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M D Threadgill

Explore the profile of M D Threadgill including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 50
Citations 240
Followers 0
Related Specialties
Pharmacology
Biochemistry
Chemistry
Top 10 Co-Authors
A Gescher
I J Stratford
M A Naylor
J A Hickman
G E Adams
E M Fielden
P B Farmer
D Ross
B D Cunningham
M A Stephens
Published In
Biochem Pharmacol
Bioorg Med Chem
J Med Chem
Anticancer Drug Des
J Pharmacol Exp Ther
Affiliations
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Recent Articles
1.
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study]
Wu C, Xiao M, Wang Y, Threadgill M, Li M, Tang Y, et al.
Mol Biol (Mosk) . 2020 May; 54(2):252-261. PMID: 32392194
PARP10 is an intracellular mono-ADP ribosyltransferase and recent reports suggest that it regulates proliferation of some cell types. However, its effect on the proliferation of colorectal carcinoma cells has not...
2.
Decreasing P-selectin and ICAM-1 via activating Akt: a possible mechanism by which PARG inhibits adhesion of mouse colorectal carcinoma CT26 cells to platelets
Yan J, Li M, Threadgill M, Wang Y, Fu W
Cancer Gene Ther . 2013 Aug; 20(9):487-92. PMID: 23949281
Poly (ADP-ribose) glycohydrolase (PARG), which was discovered during studies on DNA damage study and in inflammation research, is an attractive target protein in current cancer research. The enzymatic hydrolysis of...
3.
Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischemia and after reperfusion
Hendryk S, Czuba Z, Jedrzejowska-Szypulka H, Szliszka E, Phillips V, Threadgill M, et al.
J Physiol Pharmacol . 2009 Feb; 59(4):811-22. PMID: 19212013
Stimulation of neutrophils by different factors increases their oxidative activity and the free radicals produced can report on the degree of activation. Poly(adenosine 5'-diphosphate ribose)polymerase-1 (PARP-1), a nuclear enzyme activated...
4.
5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size
Wayman N, McDonald M, Thompson A, Threadgill M, Thiemermann C
Eur J Pharmacol . 2001 Nov; 430(1):93-100. PMID: 11698068
This study investigates the effects of a novel, water-soluble inhibitor of the activity of poly (adenosine 5'-diphosphate ribose) polymerase, 5-aminoisoquinolinone [5-aminoisoquinolin-1(2H)-one], on (i) poly (adenosine 5'-diphosphate ribose) polymerase activity in...
5.
Synthesis and characterisation of polyamine-poly(ethylene glycol) constructs for DNA binding and gene delivery
Garrett S, Davies O, Milroy D, Wood P, Pouton C, Threadgill M
Bioorg Med Chem . 2000 Sep; 8(7):1779-97. PMID: 10976527
Improved non-viral vector systems are needed for efficient delivery of DNA to target cell nuclei in gene therapy. A series of linear polyamine poly(ethylene glycol) (PEG) constructs has been synthesised...
6.
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock
McDonald M, Mota-Filipe H, Wright J, Abdelrahman M, Threadgill M, Thompson A, et al.
Br J Pharmacol . 2000 Jun; 130(4):843-50. PMID: 10864891
Poly (ADP-ribose) synthetase (PARP) is a nuclear enzyme activated by strand breaks in DNA, which are caused inter alia by reactive oxygen species (ROS). Here we report on (i) a...
7.
A biodegradable multiblock co-polymer derived from an alpha, omega-bis(methylamino)peptide and an alpha, omega-bis(oxiranylmethyl)poly(ethylene glycol)
Matthews1 S, Pouton C, Threadgill M
J Control Release . 2000 May; 67(2-3):129-39. PMID: 10825548
A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation...
8.
Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor
Ulhaq S, Chinje E, Naylor M, Jaffar M, Stratford I, Threadgill M
Bioorg Med Chem . 1999 Oct; 7(9):1787-96. PMID: 10530926
L-Thiocitrulline is a known potent inhibitor of several isoforms of nitric oxide synthase (NOS). To explore the structure-activity relationships (SARs) for this molecule in more depth than has previously been...
9.
2-nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the PARP inhibitor 5-bromoisoquinolinone
Parveen I, Naughton D, Whish W, Threadgill M
Bioorg Med Chem Lett . 1999 Aug; 9(14):2031-6. PMID: 10450975
5-Chloromethyl-1-methyl-2-nitroimidazole reacted efficiently with the anion derived from 5-bromoisoquinolin-1-one to give 5-bromo-2-((1-methyl-2-nitroimidazol-5-yl)methyl)isoquinolin -1-one. Biomimetic reduction effected release of the 5-bromoisoquinolin-1-one. The 2-nitroimidazol-5-ylmethyl unit thus has potential for development as a...
10.
Synthesis of thiophenecarboxamides, thieno[3,4-c]pyridin-4(5H)-ones and thieno[3,4-d]pyrimidin-4(3H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)
Shinkwin A, Whish W, Threadgill M
Bioorg Med Chem . 1999 Apr; 7(2):297-308. PMID: 10218821
Inhibitors of poly(ADP-ribose)polymerase (PARP) inhibit repair of damaged DNA and thus potentiate radiotherapy and chemotherapy of cancer. Treatment of 3-cyanothiophene with potassium nitrate and concentrated sulphuric acid gave 5-nitrothiophene-3-carboxamide. 4-Nitrothiophene-2-carboxamide...