I J Stratford
Overview
Explore the profile of I J Stratford including associated specialties, affiliations and a list of published articles.
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Articles
202
Citations
3076
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Recent Articles
1.
Searle E, Illidge T, Stratford I
Clin Oncol (R Coll Radiol)
. 2014 Mar;
26(5):266-76.
PMID: 24602563
Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy. There are good preclinical data to suggest this...
2.
Adams G, Flockhart I, Smithen C, Stratford I, Wardman P, Watts M
Radiat Res
. 2012 Aug;
178(2):AV183-9.
PMID: 22870968
No abstract available.
3.
Harrington K, Billingham L, Brunner T, Burnet N, Chan C, Hoskin P, et al.
Br J Cancer
. 2011 Jul;
105(5):628-39.
PMID: 21772330
No abstract available.
4.
Lunt S, Cawthorne C, Ali M, Telfer B, Babur M, Smigova A, et al.
Br J Cancer
. 2010 Jul;
103(2):201-8.
PMID: 20588272
Background: Metastases cause most cancer-related deaths. We investigated the use of hypoxia-selective cytotoxins as adjuvants to radiotherapy in the control of metastatic tumour growth. Methods: The NLCQ-1, RB6145 and tirapazamine...
5.
Workman P, Aboagye E, Balkwill F, Balmain A, Bruder G, Chaplin D, et al.
Br J Cancer
. 2010 May;
102(11):1555-77.
PMID: 20502460
Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent...
6.
Maughan T, Illidge T, Hoskin P, McKenna W, Brunner T, Stratford I, et al.
Clin Oncol (R Coll Radiol)
. 2010 Apr;
22(8):707-9.
PMID: 20363111
No abstract available.
7.
Nolan K, Humphries M, Bryce R, Stratford I
Bioorg Med Chem Lett
. 2010 Apr;
20(9):2832-6.
PMID: 20356739
The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity....
8.
Roberts D, Williams K, Cowen R, Barathova M, Eustace A, Brittain-Dissont S, et al.
Br J Cancer
. 2009 Sep;
101(8):1290-7.
PMID: 19755992
Background: Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although the mechanistic basis is unclear. This study sought to...
9.
Williams K, Telfer B, Shannon A, Babur M, Stratford I, Wedge S
Br J Radiol
. 2008 Oct;
81 Spec No 1:S21-7.
PMID: 18819995
A number of pre-clinical studies have suggested that blocking vascular endothelial growth factor (VEGF) signalling can be beneficial in combination with radiotherapy. This study investigated the effects of cediranib, a...
10.
Seenath M, Roberts D, Cawthorne C, Saunders M, Armstrong G, ODwyer S, et al.
Br J Cancer
. 2008 Jul;
99(3):459-63.
PMID: 18648372
Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed...