A Gescher
Overview
Explore the profile of A Gescher including associated specialties, affiliations and a list of published articles.
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Articles
139
Citations
1123
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Recent Articles
1.
Schiller C, Kainz A, Mynett K, Gescher A
Toxicol In Vitro
. 2010 Aug;
6(6):575-8.
PMID: 20732160
The viability and state of proliferation of cells in culture is conveniently assessed using MTT, which is metabolically reduced to stain functionally intact cells. The hypothesis was tested that this...
2.
DIncalci M, Brunelli D, Marangon E, Simone M, Tavecchio M, Gescher A, et al.
Curr Pharm Des
. 2007 Sep;
13(27):2744-50.
PMID: 17897020
Drug design based on the structure of specific enzymes playing a role in carcinogenesis, e.g. tyrosine kinases, has been successful at identifying novel effective anticancer drugs. In contrast, no success...
3.
Grosso F, Dileo P, Sanfilippo R, Stacchiotti S, Bertulli R, Piovesan C, et al.
Eur J Cancer
. 2006 Jun;
42(10):1484-90.
PMID: 16737808
Trabectedin is a marine-derived cytoxic alkaloid which has shown promising antitumour activity in a variety of human malignancies including sarcoma. Fifty-four patients with advanced sarcoma (age 43 yrs, range 18-70),...
4.
Gescher A
J Chemother
. 2005 Feb;
16 Suppl 4:3-6.
PMID: 15688599
Non steroidal antiinflammatory drugs (NSAIDs) delay the onset of cancer in rodent models of colorectal carcinogenesis. Clinical trials suggest that they can interfere with preneoplasia in humans; thus they may...
5.
Garcea G, Lloyd T, Gescher A, Dennison A, Steward W, Berry D
Eur J Cancer
. 2004 Jun;
40(9):1302-13.
PMID: 15177488
Angiogenesis is an obligatory event for the growth of tumours beyond 2 mm in diameter, above which simple oxygen diffusion can no longer support the rapid proliferation of malignant cells....
6.
Ratan H, Gescher A, Steward W, Mellon J
BJU Int
. 2003 Nov;
92(9):890-5.
PMID: 14632841
No abstract available.
7.
Perkins S, Clarke A, Steward W, Gescher A
Br J Cancer
. 2003 Jun;
88(9):1480-3.
PMID: 12778080
The nonsteroidal anti-inflammatory drug aspirin and the spice curcumin retard adenoma formation when administered long-term to Apc(Min/+) mice, a model of human familial adenomatous polyposis coli. Both agents interfere with...
8.
Garcea G, Sharma R, Dennison A, Steward W, Gescher A, Berry D
Eur J Cancer
. 2003 May;
39(8):1041-52.
PMID: 12736102
Modern medicine is increasingly focused towards population surveillance for disease, coupled with the implementation of preventative measures applied to 'at-risk' patients. Surveillance in colorectal cancer is limited by the cost...
9.
Brunner N, Double J, Fichtner I, Gescher A, Newell D, Oosterhuis W, et al.
Eur J Cancer
. 2002 Feb;
38 Suppl 4:S14-8.
PMID: 11858958
The Laboratory Research Division (LRD) of the EORTC currently consists of five Groups with expertise that includes pre-clinical drug development, all aspects of cancer pharmacology, clinically-relevant receptor and biomarker studies,...
10.
Tullett J, Rees D, Shuker D, Gescher A
Biochem Pharmacol
. 2001 Nov;
62(9):1239-47.
PMID: 11705457
S-Nitrosothiols (RSNOs) have been widely studied as donors of nitric oxide. In general, RSNOs are considered to be somewhat unstable; however, they are both potent vasodilators and inhibitors of platelet...