Luke L McGoldrick
Overview
Explore the profile of Luke L McGoldrick including associated specialties, affiliations and a list of published articles.
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15
Citations
569
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0
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Recent Articles
1.
Hoque M, Grigg J, Ramlall T, Jones J, McGoldrick L, Lin J, et al.
Nat Commun
. 2025 Jan;
16(1):318.
PMID: 39747888
The T-cell receptor (TCR)/CD3 complex plays an essential role in the immune response and is a key player in cancer immunotherapies. There are two classes of TCR/CD3 complexes, defined by...
2.
Saotome K, McGoldrick L, Ho J, Ramlall T, Shah S, Moore M, et al.
Nat Struct Mol Biol
. 2024 Sep;
32(2):315-325.
PMID: 39313635
Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the architecture of an inactive, homodimeric receptor. However,...
3.
Wang H, McGoldrick L, Chung J
Nat Rev Urol
. 2020 Nov;
18(1):46-66.
PMID: 33214707
Mammalian sperm cells must respond to cues originating from along the female reproductive tract and from the layers of the egg in order to complete their fertilization journey. Dynamic regulation...
4.
McGoldrick L, Chung J
Elife
. 2020 Feb;
9.
PMID: 32105216
An automated high-throughput platform can screen for molecules that change the motility of sperm cells and their ability to fertilize.
5.
Singh A, McGoldrick L, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky A
Nat Struct Mol Biol
. 2020 Jan;
27(2):221.
PMID: 31932763
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
6.
Singh A, McGoldrick L, Demirkhanyan L, Leslie M, Zakharian E, Sobolevsky A
Nat Struct Mol Biol
. 2019 Oct;
26(11):994-998.
PMID: 31636415
We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel...
7.
McGoldrick L, Singh A, Demirkhanyan L, Lin T, Casner R, Zakharian E, et al.
Nat Commun
. 2019 Sep;
10(1):4180.
PMID: 31519888
Algae produce the largest amount of oxygen on earth and are invaluable for human nutrition and biomedicine, as well as for the chemical industry, energy production and agriculture. The mechanisms...
8.
Elmes M, Prentis L, McGoldrick L, Giuliano C, Sweeney J, Joseph O, et al.
Sci Rep
. 2019 May;
9(1):7588.
PMID: 31110286
The increasing use of medical marijuana highlights the importance of developing a better understanding of cannabinoid metabolism. Phytocannabinoids, including ∆-tetrahydrocannabinol (THC), are metabolized and inactivated by cytochrome P450 enzymes primarily...
9.
Singh A, McGoldrick L, Sobolevsky A
Methods Mol Biol
. 2019 Apr;
1987:23-37.
PMID: 31028671
Transient receptor potential (TRP) channels are polymodal sensory transducers that respond to chemicals, temperature, mechanical stress, and membrane voltage and are involved in vision, taste, olfaction, hearing, touch, thermal perception,...
10.
Singh A, McGoldrick L, Sobolevsky A
Nat Struct Mol Biol
. 2018 Aug;
25(9):805-813.
PMID: 30127359
Transient receptor potential vanilloid subfamily member 3 (TRPV3) channel plays a crucial role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with various skin diseases, including Olmsted syndrome,...