William C Olson
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Explore the profile of William C Olson including associated specialties, affiliations and a list of published articles.
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73
Citations
3284
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Recent Articles
1.
Hoque M, Grigg J, Ramlall T, Jones J, McGoldrick L, Lin J, et al.
Nat Commun
. 2025 Jan;
16(1):318.
PMID: 39747888
The T-cell receptor (TCR)/CD3 complex plays an essential role in the immune response and is a key player in cancer immunotherapies. There are two classes of TCR/CD3 complexes, defined by...
2.
Zhou Y, Stevis P, Cao J, Ehrlich G, Jones J, Rafique A, et al.
Nat Commun
. 2024 Nov;
15(1):9776.
PMID: 39532904
Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes. While type I...
3.
Wu J, Bloch N, Chang A, Bhavsar R, Wang Q, Crawford A, et al.
Cell Rep Med
. 2024 Sep;
5(10):101747.
PMID: 39326410
The clinical use of interleukin-2 (IL-2) for cancer immunotherapy is limited by severe toxicity. Emerging IL-2 therapies with reduced IL-2 receptor alpha (IL-2Rα) binding aim to mitigate toxicity and regulatory...
4.
Saotome K, McGoldrick L, Ho J, Ramlall T, Shah S, Moore M, et al.
Nat Struct Mol Biol
. 2024 Sep;
32(2):315-325.
PMID: 39313635
Activation of the chemokine receptor CXCR4 by its chemokine ligand CXCL12 regulates diverse cellular processes. Previously reported crystal structures of CXCR4 revealed the architecture of an inactive, homodimeric receptor. However,...
5.
Altarejos J, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert A, et al.
Sci Transl Med
. 2023 Nov;
15(723):eadd4897.
PMID: 37992152
Deficiency in the adipose-derived hormone leptin or leptin receptor signaling causes class 3 obesity in individuals with genetic loss-of-function mutations in leptin or its receptor LEPR and metabolic and liver...
6.
Saotome K, Dudgeon D, Colotti K, Moore M, Jones J, Zhou Y, et al.
Nat Commun
. 2023 Apr;
14(1):2401.
PMID: 37100770
The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing...
7.
Zhou Y, Stevis P, Cao J, Saotome K, Wu J, Glatman Zaretsky A, et al.
Sci Adv
. 2023 Mar;
9(11):eade4395.
PMID: 36930708
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo-electron microscopy structures...
8.
Perez Bay A, Faulkner D, DaSilva J, Young T, Yang K, Giurleo J, et al.
Mol Cancer Ther
. 2023 Mar;
22(3):357-370.
PMID: 36861363
Most antibody-drug conjugates (ADC) approved for the treatment of cancer contain protease-cleavable linkers. ADCs that traffic to lysosomes traverse highly acidic late endosomes, while ADCs that recycle to the plasma...
9.
Tavare R, Danton M, Giurleo J, Makonnen S, Hickey C, Arnold T, et al.
Cancer Immunol Res
. 2022 Jul;
10(10):1190-1209.
PMID: 35895745
Assessment of immune-cell subsets within the tumor immune microenvironment is a powerful approach to better understand cancer immunotherapy responses. However, the use of biopsies to assess the tumor immune microenvironment...
10.
Devalaraja-Narashimha K, Huang C, Cao M, Chen Y, Borodovsky A, Olson W, et al.
PLoS One
. 2022 Jun;
17(6):e0269749.
PMID: 35709087
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by uncontrolled complement activation; effective and approved treatments include terminal complement inhibition. This study assessed whether combination cemdisiran (an investigational N-acetylgalactosamine-conjugated...