Alexander I Sobolevsky
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Explore the profile of Alexander I Sobolevsky including associated specialties, affiliations and a list of published articles.
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75
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2989
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Recent Articles
1.
Talyzina I, Nadezhdin K, Sobolevsky A
Curr Opin Chem Biol
. 2024 Nov;
84:102550.
PMID: 39615427
Transient receptor potential (TRP) channels are polymodal molecular sensors that integrate chemical, thermal, mechanical and electrical stimuli and convert them into ionic currents that regulate senses of taste, smell, vision,...
2.
Gangwar S, Yelshanskaya M, Aktolun M, Yen L, Newton T, Stromgaard K, et al.
Nat Commun
. 2024 Nov;
15(1):10257.
PMID: 39592599
Kainate receptors (KARs) are a subtype of ionotropic glutamate receptor (iGluR) channels, a superfamily of ligand-gated ion channels which mediate the majority of excitatory neurotransmission in the central nervous system....
3.
Neuberger A, Shalygin A, Trofimov Y, Veretenenko I, Nadezhdin K, Krylov N, et al.
Structure
. 2024 Nov;
33(1):91-103.e5.
PMID: 39500315
TRPV6 is a Ca selective channel that mediates calcium uptake in the gut and contributes to the development and progression of human cancers. TRPV6 is represented by the ancestral and...
4.
Zhao L, Xu K, Talyzina I, Shi J, Li S, Yang Y, et al.
bioRxiv
. 2024 Oct;
PMID: 39464052
Sonogenetics offers non-invasive and cell-type specific modulation of cells genetically engineered to express ultrasound-sensitive actuators. Finding an ion channel to serve as sonogenetic actuator it critical for advancing this promising...
5.
Trofimov Y, Krylov N, Minakov A, Nadezhdin K, Neuberger A, Sobolevsky A, et al.
Commun Chem
. 2024 Jun;
7(1):119.
PMID: 38824263
Structural biology is solving an ever-increasing number of snapshots of ion channel conformational ensembles. Deciphering ion channel mechanisms, however, requires understanding the ensemble dynamics beyond the static structures. Here, we...
6.
Gangwar S, Yelshanskaya M, Nadezhdin K, Yen L, Newton T, Aktolun M, et al.
Nature
. 2024 May;
630(8017):762-768.
PMID: 38778115
Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated ion channels that mediate excitatory neurotransmission. Kainate receptors modulate neuronal circuits and synaptic plasticity during the development and function...
7.
Nadezhdin K, Neuberger A, Khosrof L, Talyzina I, Khau J, Yelshanskaya M, et al.
Sci Adv
. 2024 May;
10(18):eadn2453.
PMID: 38691614
TRPV3 represents both temperature- and ligand-activated transient receptor potential (TRP) channel. Physiologically relevant opening of TRPV3 channels by heat has been captured structurally, while opening by agonists has only been...
8.
Nadezhdin K, Correia L, Shalygin A, Aktolun M, Neuberger A, Gudermann T, et al.
Cell Rep
. 2024 Apr;
43(4):114108.
PMID: 38615321
TRP channels are implicated in various diseases, but high structural similarity between them makes selective pharmacological modulation challenging. Here, we study the molecular mechanism underlying specific inhibition of the TRPM7...
9.
Vukolova M, Yen L, Khmyz M, Sobolevsky A, Yelshanskaya M
Front Cell Dev Biol
. 2023 Nov;
11:1252953.
PMID: 38033869
Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes,...
10.
Banerjee P, Holehouse A, Kriwacki R, Robustelli P, Jiang H, Sobolevsky A, et al.
Trends Biochem Sci
. 2023 Nov;
49(2):101-104.
PMID: 37949765
Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current...