Edward C Twomey
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Explore the profile of Edward C Twomey including associated specialties, affiliations and a list of published articles.
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19
Citations
729
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Recent Articles
1.
Hale W, Romero A, Koylass N, Warrick C, Qiu Z, Huganir R, et al.
Nat Commun
. 2025 Jan;
16(1):671.
PMID: 39809794
Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. With cryo-electron microscopy (cryo-EM) we reconstruct the 36 kDa...
2.
Mondal A, Carrillo E, Jayaraman V, Twomey E
bioRxiv
. 2024 Sep;
PMID: 39282358
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that mediate the majority of excitatory neurotransmission. iGluRs are gated by glutamate, where upon glutamate binding, they open their ion channels...
3.
Carrillo E, Romero A, Gonzalez C, Turcu A, Chen S, Chen H, et al.
bioRxiv
. 2024 Jul;
PMID: 39005433
Memantine is an US Food and Drug Administration (FDA) approved drug that selectively inhibits NMDA-subtype ionotropic glutamate receptors (NMDARs) for treatment of dementia and Alzheimer's. NMDARs enable calcium influx into...
4.
Hale W, Romero A, Gonzalez C, Jayaraman V, Lau A, Huganir R, et al.
Nat Struct Mol Biol
. 2024 Jun;
31(11):1669-1679.
PMID: 38834914
Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to...
5.
Romero A, Bonin C, Twomey E
IUCrJ
. 2023 Dec;
11(Pt 1):16-22.
PMID: 38096039
Molecular structures can be determined in vitro and in situ with cryo-electron microscopy (cryo-EM). Specimen preparation is a major obstacle in cryo-EM. Typical sample preparation is orders of magnitude slower...
6.
Hale W, Romero A, Gonzalez C, Jayaraman V, Lau A, Huganir R, et al.
bioRxiv
. 2023 Dec;
PMID: 38076818
Excitatory neurotransmission is principally mediated by AMPA-subtype ionotropic glutamate receptors (AMPARs). Dysregulation of AMPARs is the cause of many neurological disorders and how therapeutic candidates such as negative allosteric modulators...
7.
Hale W, Romero A, Huganir R, Twomey E
bioRxiv
. 2023 Dec;
PMID: 38076787
Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. We used cryo-electron microscopy (cryo-EM) to reconstruct the 36...
8.
9.
Twomey E, Yelshanskaya M, Sobolevsky A
J Gen Physiol
. 2019 Oct;
151(12):1347-1356.
PMID: 31615831
Fast excitatory neurotransmission is mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of ionotropic glutamate receptor (AMPAR). AMPARs initiate depolarization of the postsynaptic neuron by allowing cations to enter through their...
10.
Twomey E, Ji Z, Wales T, Bodnar N, Ficarro S, Marto J, et al.
Science
. 2019 Jun;
365(6452).
PMID: 31249135
The Cdc48 adenosine triphosphatase (ATPase) (p97 or valosin-containing protein in mammals) and its cofactor Ufd1/Npl4 extract polyubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by the proteasome. How...