Lukasz J Sznajder
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Explore the profile of Lukasz J Sznajder including associated specialties, affiliations and a list of published articles.
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19
Citations
488
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Recent Articles
11.
Thomas J, Oliveira R, Sznajder L, Swanson M
Compr Physiol
. 2018 Apr;
8(2):509-553.
PMID: 29687899
Myotonic dystrophy (DM) is a multisystemic disorder caused by microsatellite expansion mutations in two unrelated genes leading to similar, yet distinct, diseases. DM disease presentation is highly variable and distinguished...
12.
Sznajder L, Thomas J, Carrell E, Reid T, McFarland K, Cleary J, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(16):4234-4239.
PMID: 29610297
Expansions of simple sequence repeats, or microsatellites, have been linked to ∼30 neurological-neuromuscular diseases. While these expansions occur in coding and noncoding regions, microsatellite sequence and repeat length diversity is...
13.
Cywoniuk P, Taylor K, Sznajder L, Sobczak K
Sci Rep
. 2017 Dec;
7(1):17587.
PMID: 29242583
Alternative splicing is a complex process that provides a high diversity of proteins from a limited number of protein-coding genes. It is governed by multiple regulatory factors, including RNA-binding proteins...
14.
Thomas J, Sznajder L, Bardhi O, Aslam F, Anastasiadis Z, Scotti M, et al.
Genes Dev
. 2017 Jul;
31(11):1122-1133.
PMID: 28698297
Myotonic dystrophy type 1 (DM1) is a CTG microsatellite expansion (CTG) disorder caused by expression of CUG RNAs. These mutant RNAs alter the activities of RNA processing factors, including MBNL...
15.
Konieczny P, Stepniak-Konieczna E, Taylor K, Sznajder L, Sobczak K
Nucleic Acids Res
. 2016 Dec;
45(4):1760-1775.
PMID: 27903900
Muscleblind-like proteins (MBNLs) are regulators of RNA metabolism. During tissue differentiation the level of MBNLs increases, while their functional insufficiency plays a crucial role in myotonic dystrophy (DM). Deep sequencing...
16.
Sznajder L, Michalak M, Taylor K, Cywoniuk P, Kabza M, Wojtkowiak-Szlachcic A, et al.
Nucleic Acids Res
. 2016 Oct;
44(21):10326-10342.
PMID: 27733504
Muscleblind-like (MBNL) proteins are critical RNA processing factors in development. MBNL activity is disrupted in the neuromuscular disease myotonic dystrophy type 1 (DM1), due to the instability of a non-coding...
17.
Wojtkowiak-Szlachcic A, Taylor K, Stepniak-Konieczna E, Sznajder L, Mykowska A, Sroka J, et al.
Nucleic Acids Res
. 2015 Mar;
43(6):3318-31.
PMID: 25753670
Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder caused by expansion of CTG triplet repeats in 3'-untranslated region of DMPK gene. The pathomechanism of DM1 is driven...
18.
Kumar A, Parkesh R, Sznajder L, Childs-Disney J, Sobczak K, Disney M
ACS Chem Biol
. 2012 Jan;
7(3):496-505.
PMID: 22252896
Recently, it was reported that expanded r(CAG) triplet repeats (r(CAG)(exp)) associated with untreatable neurological diseases cause pre-mRNA mis-splicing likely due to sequestration of muscleblind-like 1 (MBNL1) splicing factor. Bioactive small...
19.
Koscianska E, Starega-Roslan J, Sznajder L, Olejniczak M, Galka-Marciniak P, Krzyzosiak W
BMC Mol Biol
. 2011 Apr;
12:14.
PMID: 21481235
Background: Numerous microRNAs (miRNAs) have heterogeneous ends resulting from imprecise cleavages by processing nucleases and from various non-templated nucleotide additions. The scale of miRNA end-heterogeneity is best shown by deep...