Eric T Wang
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Explore the profile of Eric T Wang including associated specialties, affiliations and a list of published articles.
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77
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7456
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Recent Articles
1.
Nguyen L, Ajredini R, Guo S, Romano L, Tomas R, Bell L, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(7):e2416885122.
PMID: 39937857
Alzheimer's disease (AD) affects more than 10% of the population ≥65 y of age, but the underlying biological risks of most AD cases are unclear. We show anti-poly-glycine-arginine (a-polyGR) positive...
2.
Poukalov K, Valero M, Muscato D, Adams L, Chun H, Lee Y, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(19):e2321438121.
PMID: 38687782
Successful CRISPR/Cas9-based gene editing in skeletal muscle is dependent on efficient propagation of Cas9 to all myonuclei in the myofiber. However, nuclear-targeted gene therapy cargos are strongly restricted to their...
3.
Denes L, Kelley C, Wang E
Methods Mol Biol
. 2024 Mar;
2784:163-176.
PMID: 38502485
RNA fluorescence in situ hybridization (FISH) is a powerful method to determine the abundance and localization of mRNA molecules in cells. While modern RNA FISH techniques allow quantification at single...
4.
Poukalov K, Valero M, Muscato D, Adams L, Chun H, Lee Y, et al.
bioRxiv
. 2023 Nov;
PMID: 37986992
Successful CRISPR/Cas9-based gene editing in skeletal muscle is dependent on efficient propagation of Cas9 to all myonuclei in the myofiber. However, nuclear-targeted gene therapy cargos are strongly restricted to their...
5.
Gibaut Q, Bush J, Tong Y, Baisden J, Taghavi A, Olafson H, et al.
ACS Cent Sci
. 2023 Jul;
9(7):1342-1353.
PMID: 37521782
Myotonic dystrophy type 1 (DM1) is caused by a highly structured RNA repeat expansion, r(CUG), harbored in the 3' untranslated region (3' UTR) of dystrophia myotonica protein kinase () mRNA...
6.
Hildebrandt R, Moss K, Janusz-Kaminska A, Knudson L, Denes L, Saxena T, et al.
Nat Commun
. 2023 Jun;
14(1):3427.
PMID: 37296096
RNA binding proteins (RBPs) act as critical facilitators of spatially regulated gene expression. Muscleblind-like (MBNL) proteins, implicated in myotonic dystrophy and cancer, localize RNAs to myoblast membranes and neurites through...
7.
Ellis J, Hale M, Cleary J, Wang E, Berglund J
J Mol Biol
. 2023 May;
435(15):168156.
PMID: 37230319
Alternative splicing (AS) is a dynamic RNA processing step that produces multiple RNA isoforms from a single pre-mRNA transcript and contributes to the complexity of the cellular transcriptome and proteome....
8.
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1
Nutter C, Kidd B, Carter H, Hamel J, Mackie P, Kumbkarni N, et al.
Brain
. 2023 May;
146(10):4217-4232.
PMID: 37143315
Myotonic dystrophy type 1 is a dominantly inherited multisystemic disease caused by CTG tandem repeat expansions in the DMPK 3' untranslated region. These expanded repeats are transcribed and produce toxic...
9.
Wang E, Freudenreich C, Gromak N, Jain A, Todd P, Nagai Y
Mol Cell
. 2023 Feb;
83(3):324-329.
PMID: 36736306
Pathogenic repeat sequences underlie several human disorders, including amyotrophic lateral sclerosis, Huntington's disease, and myotonic dystrophy. Here, we speak to several researchers about how repeat sequences have been implicated in...
10.
Bagley J, Denes L, McCarthy J, Wang E, Murach K
J Physiol
. 2023 Jan;
601(4):723-741.
PMID: 36629254
Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which complicates the equitable distribution of...