Curtis A Nutter
Overview
Explore the profile of Curtis A Nutter including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
338
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Recent Articles
1.
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1
Nutter C, Kidd B, Carter H, Hamel J, Mackie P, Kumbkarni N, et al.
Brain
. 2023 May;
146(10):4217-4232.
PMID: 37143315
Myotonic dystrophy type 1 is a dominantly inherited multisystemic disease caused by CTG tandem repeat expansions in the DMPK 3' untranslated region. These expanded repeats are transcribed and produce toxic...
2.
Cooper A, Nutter C, Kuyumcu-Martinez M, Wright C
Mol Cell Biol
. 2022 Apr;
42(5):e0050321.
PMID: 35404107
Aberrant alternative splicing (AS) of pre-mRNAs promotes the development and proliferation of cancerous cells. Accordingly, we had previously observed higher levels of the aryl hydrocarbon receptor nuclear translocator (ARNT) spliced...
3.
Batra R, Nelles D, Roth D, Krach F, Nutter C, Tadokoro T, et al.
Nat Biomed Eng
. 2020 Sep;
5(2):157-168.
PMID: 32929188
Myotonic dystrophy type I (DM1) is a multisystemic autosomal-dominant inherited human disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3' untranslated region of DMPK. Toxic RNAs...
4.
Sznajder L, Scotti M, Shin J, Taylor K, Ivankovic F, Nutter C, et al.
Nat Commun
. 2020 Apr;
11(1):2022.
PMID: 32332745
The thymus is a primary lymphoid organ that plays an essential role in T lymphocyte maturation and selection during development of one arm of the mammalian adaptive immune response. Although...
5.
Li M, Zhuang Y, Batra R, Thomas J, Li M, Nutter C, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(10):5472-5477.
PMID: 32086392
Studies on myotonic dystrophy type 1 (DM1) have led to the RNA-mediated disease model for hereditary disorders caused by noncoding microsatellite expansions. This model proposes that DM1 disease manifestations are...
6.
Nutter C, Bubenik J, Oliveira R, Ivankovic F, Sznajder L, Kidd B, et al.
Genes Dev
. 2019 Oct;
33(23-24):1635-1640.
PMID: 31624084
Short tandem repeats (STRs) are prone to expansion mutations that cause multiple hereditary neurological and neuromuscular diseases. To study pathomechanisms using mouse models that recapitulate the tissue specificity and developmental...
7.
Belanger K, Nutter C, Li J, Yu P, Kuyumcu-Martinez M
Biochem Biophys Res Commun
. 2018 Dec;
509(2):384-389.
PMID: 30594394
Alternative splicing (AS) is dysregulated in Type 1 diabetic (T1D) hearts but mechanisms responsible are unclear. Here, we provide evidence that the RNA binding protein (RBP) PTBP1 is modulated in...
8.
Belanger K, Nutter C, Li J, Tasnim S, Liu P, Yu P, et al.
Biochem Biophys Res Commun
. 2018 Aug;
503(4):3205-3211.
PMID: 30158053
Dysregulated alternative splicing (AS) that contributes to diabetes pathogenesis has been identified, but little is known about the RNA binding proteins (RBPs) involved. We have previously found that the RBP...
9.
Sznajder L, Thomas J, Carrell E, Reid T, McFarland K, Cleary J, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(16):4234-4239.
PMID: 29610297
Expansions of simple sequence repeats, or microsatellites, have been linked to ∼30 neurological-neuromuscular diseases. While these expansions occur in coding and noncoding regions, microsatellite sequence and repeat length diversity is...
10.
Nutter C, Kuyumcu-Martinez M
Wiley Interdiscip Rev RNA
. 2017 Dec;
9(2).
PMID: 29280295
Diabetes is a debilitating health care problem affecting 422 million people around the world. Diabetic patients suffer from multisystemic complications that can cause mortality and morbidity. Recent advancements in high-throughput...