Luis A Vale-Silva
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Explore the profile of Luis A Vale-Silva including associated specialties, affiliations and a list of published articles.
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381
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Recent Articles
1.
Rahimi A, Vale-Silva L, Falth Savitski M, Tanevski J, Saez-Rodriguez J
Nat Commun
. 2024 Jun;
15(1):4994.
PMID: 38862466
Single-cell transcriptomics and spatially-resolved imaging/sequencing technologies have revolutionized biomedical research. However, they suffer from lack of spatial information and a trade-off of resolution and gene coverage, respectively. We propose DOT,...
2.
Luo J, Vale-Silva L, Raghavan A, Mercy G, Heldrich J, Sun X, et al.
Cell Genom
. 2023 Nov;
3(11):100439.
PMID: 38020967
We designed and synthesized , which is ∼21.6% shorter than native , the smallest chromosome in . was designed for attachment to another synthetic chromosome due to concerns surrounding potential...
3.
Heldrich J, Milano C, Markowitz T, Ur S, Vale-Silva L, Corbett K, et al.
Nucleic Acids Res
. 2022 Apr;
50(8):4545-4556.
PMID: 35412621
Successful meiotic recombination, and thus fertility, depends on conserved axis proteins that organize chromosomes into arrays of anchored chromatin loops and provide a protected environment for DNA exchange. Here, we...
4.
Vale-Silva L, Rohr K
Sci Rep
. 2021 Jun;
11(1):13505.
PMID: 34188098
The age of precision medicine demands powerful computational techniques to handle high-dimensional patient data. We present MultiSurv, a multimodal deep learning method for long-term pan-cancer survival prediction. MultiSurv uses dedicated...
5.
Heldrich J, Sun X, Vale-Silva L, Markowitz T, Hochwagen A
Genetics
. 2020 Mar;
215(1):59-73.
PMID: 32152049
During meiotic prophase, concurrent transcription, recombination, and chromosome synapsis place substantial topological strain on chromosomal DNA, but the role of topoisomerases in this context remains poorly defined. Here, we analyzed...
6.
Subramanian V, Zhu X, Markowitz T, Vale-Silva L, San-Segundo P, Hollingsworth N, et al.
Nat Commun
. 2019 Mar;
10(1):970.
PMID: 30814509
Faithful meiotic chromosome inheritance and fertility rely on the stimulation of meiotic crossover recombination by potentially genotoxic DNA double-strand breaks (DSBs). To avoid excessive damage, feedback mechanisms down-regulate DSBs, likely...
7.
Vale-Silva L, Markowitz T, Hochwagen A
BMC Genomics
. 2019 Jan;
20(1):54.
PMID: 30654749
Background: Chromatin-immunoprecipitation followed by sequencing (ChIP-seq) is the method of choice for mapping genome-wide binding of chromatin-associated factors. However, broadly applicable methods for between-sample comparisons are lacking. Results: Here, we...
8.
Vale-Silva L, Moeckli B, Torelli R, Posteraro B, Sanguinetti M, Sanglard D
mSphere
. 2016 Jun;
1(2).
PMID: 27303714
Candida glabrata is the second most common Candida species causing disseminated infection, after C. albicans. C. glabrata is intrinsically less susceptible to the widely used azole antifungal drugs and quickly...
9.
Nishikawa J, Boeszoermenyi A, Vale-Silva L, Torelli R, Posteraro B, Sohn Y, et al.
Nature
. 2016 Feb;
530(7591):485-9.
PMID: 26886795
Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex. Aberrant function of transcription activators has...
10.
Vale-Silva L, Sanglard D
FEMS Yeast Res
. 2015 May;
15(4):fov025.
PMID: 25979690
Among existing fungal pathogens, Candida glabrata is outstanding in its capacity to rapidly develop resistance to currently used antifungal agents. Resistance to the class of azoles, which are still widely...