Luis A Vale-Silva
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Explore the profile of Luis A Vale-Silva including associated specialties, affiliations and a list of published articles.
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381
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Recent Articles
11.
Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals
Eddouzi J, Parker J, Vale-Silva L, Coste A, Ischer F, Kelly S, et al.
Antimicrob Agents Chemother
. 2013 May;
57(7):3182-93.
PMID: 23629718
Antifungal resistance of Candida species is a clinical problem in the management of diseases caused by these pathogens. In this study we identified from a collection of 423 clinical samples...
12.
Calhelha R, Ferreira I, Peixoto D, Abreu R, Vale-Silva L, Pinto E, et al.
Molecules
. 2012 Mar;
17(4):3834-43.
PMID: 22456543
Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding...
13.
Abreu A, Castanheira E, Queiroz M, Ferreira P, Vale-Silva L, Pinto E
Nanoscale Res Lett
. 2011 Aug;
6(1):482.
PMID: 21812989
A potential antitumoral fluorescent indole derivative, methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate, was evaluated for the in vitro cell growth inhibition on three human tumor cell lines, MCF-7 (breast adenocarcinoma), A375-C5 (melanoma), and NCI-H460...
14.
Queiroz M, Calhelha R, Vale-Silva L, Pinto E, Almeida G, Vasconcelos M
Eur J Med Chem
. 2010 Dec;
46(1):236-40.
PMID: 21138784
The methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate, recently reported by some of us, was reacted in Sonogashira couplings with several (hetero)arylacetylenes. The growth inhibitory activity of the novel methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates obtained was evaluated on...
15.
Queiroz M, Calhelha R, Vale-Silva L, Pinto E, Sao-Jose Nascimento M
Eur J Med Chem
. 2010 Oct;
45(12):5732-8.
PMID: 20934235
Several novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines were prepared by palladium-catalyzed C-N Buchwald-Hartwig coupling of the methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate with aryl and heteroarylamines, using different reaction conditions. The antitumoral activity of the di(hetero)arylamines obtained was...
16.
Queiroz M, Calhelha R, Vale-Silva L, Pinto E, Lima R, Vasconcelos M
Eur J Med Chem
. 2010 Oct;
45(12):5628-34.
PMID: 20926160
A wide variety of new bi(hetero)aryl derivatives of the thieno[3,2-b]pyridine skeleton was obtained in high to excellent yields (65-91%) by Suzuki-Miyaura cross-coupling of the methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate, recently reported by us,...
17.
Taveira M, Silva L, Vale-Silva L, Pinto E, Valentao P, Ferreres F, et al.
J Agric Food Chem
. 2010 Aug;
58(17):9529-36.
PMID: 20707344
Lycopersicon esculentum (tomato) fruit is a widely studied matrix. However, only few works focus their attention on its seeds, which constitute a major byproduct of the tomato processing industry. In...
18.
Queiroz M, Calhelha R, Vale-Silva L, Pinto E, Sao-Jose Nascimento M
Eur J Med Chem
. 2008 Dec;
44(5):1893-9.
PMID: 19070942
Several novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones (tricyclic lactones) were prepared either by a tandem one-pot Sonogashira coupling and intramolecular cyclization, reacting the 3-bromobenzo[b]thiophene-2-carboxylic acid with arylacetylenes, or by Sonogashira coupling of the methyl...
19.
Pinto E, Queiroz M, Vale-Silva L, Oliveira J, Begouin A, Begouin J, et al.
Bioorg Med Chem
. 2008 Aug;
16(17):8172-7.
PMID: 18678498
The antifungal activity of several di(hetero)arylamine derivatives of the benzo[b]thiophene system was evaluated against clinically relevant Candida, Aspergillus, and dermatophyte species by a broth macrodilution test based on CLSI (formerly...
20.
Vale-Silva L, Buchta V, Vokurkova D, Pour M
Bioorg Med Chem Lett
. 2006 Feb;
16(9):2492-5.
PMID: 16480875
The mechanism of action of the antifungal agent 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans was investigated by flow cytometry, using propidium iodide, DiBAC4(3), and FUN-1 as the fluorescent dyes. A related but...