Lisa M Coussens
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Explore the profile of Lisa M Coussens including associated specialties, affiliations and a list of published articles.
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171
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29582
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Recent Articles
1.
Berens E, Khou S, Huang E, Hoffman A, Johnson B, Kirchberger N, et al.
bioRxiv
. 2025 Feb;
PMID: 39896558
Statement Of Significance: Neoplastic breast epithelial cells express surface receptors canonically attributed to leukocytes and are associated with therapy resistance and aggressive tumor behavior.
2.
Ehlers F, Blise K, Betts C, Sivagnanam S, Kooreman L, Hwang E, et al.
Breast Cancer Res
. 2025 Jan;
27(1):14.
PMID: 39856748
Tumor-infiltrating lymphocytes are considered clinically beneficial in breast cancer, but the significance of natural killer (NK) cells is less well characterized. As increasing evidence has demonstrated that the spatial organization...
3.
Link J, Eng J, Pelz C, MacPherson-Hawthorne K, Worth P, Sivagnanam S, et al.
Nat Cancer
. 2025 Jan;
6(1):123-144.
PMID: 39789181
Patients with metastatic pancreatic ductal adenocarcinoma survive longer if disease spreads to the lung but not the liver. Here we generated overlapping, multi-omic datasets to identify molecular and cellular features...
4.
Baretti M, Danilova L, Durham J, Betts C, Cope L, Sidiropoulos D, et al.
Nat Commun
. 2024 Nov;
15(1):9801.
PMID: 39532835
Pancreatic ductal adenocarcinoma (PDA) is characterized by low cytotoxic lymphocytes, abundant immune-suppressive cells, and resistance to immune checkpoint inhibitors (ICI). Preclinical PDA models showed the HDAC inhibitor entinostat reduced myeloid...
5.
Mi H, Sivagnanam S, Betts C, Liudahl S, Jaffee E, Coussens L, et al.
Cancer Res
. 2024 Nov;
84(21):3701.
PMID: 39492679
No abstract available.
6.
Kumar S, Tailor D, Dheeraj A, Li W, Stefan K, Lee J, et al.
Cell Rep Med
. 2024 Aug;
5(9):101698.
PMID: 39181134
Tumor-associated macrophages (TAMs) and other myelomonocytic cells are implicated in regulating responsiveness to immunotherapies, including immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis. We have developed an ex vivo high-throughput...
7.
Mi H, Sivagnanam S, Ho W, Zhang S, Bergman D, Deshpande A, et al.
Brief Bioinform
. 2024 Aug;
25(5).
PMID: 39179248
Advancements in imaging technologies have revolutionized our ability to deeply profile pathological tissue architectures, generating large volumes of imaging data with unparalleled spatial resolution. This type of data collection, namely,...
8.
Shepard R, Ghebremedhin A, Pratumchai I, Robinson S, Betts C, Hu J, et al.
Sci Transl Med
. 2024 Jul;
16(754):eadi6887.
PMID: 38959328
Virulent infectious agents such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methicillin-resistant (MRSA) induce tissue damage that recruits neutrophils, monocyte, and macrophages, leading to T cell exhaustion, fibrosis,...
9.
Phillips E, Alharithi Y, Kadam L, Coussens L, Kumar S, Maloyan A
Int J Obes (Lond)
. 2024 Jun;
48(11):1542-1551.
PMID: 38937647
Background/objectives: Intrauterine metabolic reprogramming occurs in mothers with obesity during gestation, putting the offspring at high risk of developing obesity and associated metabolic disorders even before birth. We have generated...
10.
Blise K, Sivagnanam S, Betts C, Betre K, Kirchberger N, Tate B, et al.
Cancer Immunol Res
. 2024 Feb;
12(5):544-558.
PMID: 38381401
Tumor molecular data sets are becoming increasingly complex, making it nearly impossible for humans alone to effectively analyze them. Here, we demonstrate the power of using machine learning (ML) to...