Ley-Hian Low
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Explore the profile of Ley-Hian Low including associated specialties, affiliations and a list of published articles.
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10
Citations
477
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Recent Articles
1.
Sterzenbach U, Putz U, Low L, Silke J, Tan S, Howitt J
Mol Ther
. 2017 Apr;
25(6):1269-1278.
PMID: 28412169
Exosomes represent an attractive vehicle for the delivery of biomolecules. However, mechanisms for loading functional molecules into exosomes are relatively unexplored. Here we report the use of the evolutionarily conserved...
2.
Howitt J, Low L, Putz U, Doan A, Lackovic J, Goh C, et al.
J Mol Cell Biol
. 2015 Mar;
7(2):119-31.
PMID: 25801959
Pten controls a signaling axis that is implicated to regulate cell proliferation, growth, survival, migration, and metabolism. The molecular mechanisms underlying the specificity of Pten responses to such diverse cellular...
3.
Low L, Chow Y, Li Y, Goh C, Putz U, Silke J, et al.
J Biol Chem
. 2015 Jan;
290(11):7141-50.
PMID: 25631046
During injury, cells are vulnerable to apoptosis from a variety of stress conditions including DNA damage causing double-stranded breaks. Without repair, these breaks lead to aberrations in DNA replication and...
4.
Putz U, Mah S, Goh C, Low L, Howitt J, Tan S
Methods
. 2014 Dec;
77-78:157-63.
PMID: 25542098
PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since...
5.
Li Y, Low L, Putz U, Goh C, Tan S, Howitt J
Traffic
. 2014 May;
15(7):749-61.
PMID: 24798731
The spatial regulation of Pten is critical for its role as a tumour suppressor with both nuclear and cytoplasmic locations being implicated with distinct functions. In the cytoplasm, Pten plays...
6.
Goh C, Putz U, Howitt J, Low L, Gunnersen J, Bye N, et al.
Exp Neurol
. 2013 Nov;
252:37-46.
PMID: 24275527
There is controversy whether accumulation of the tumor suppressor PTEN protein in the cell nucleus under stress conditions such as trauma and stroke causes cell death. A number of in...
7.
Goh C, Low L, Putz U, Gunnersen J, Hammond V, Howitt J, et al.
Neurosci Lett
. 2013 Sep;
555:225-30.
PMID: 24036464
During development, protein substrates need to be removed and degraded when they are no longer required. The E3 ubiquitin ligases, including Nedd4 family proteins, are a major group of enzymes...
8.
Hammond V, Gunnersen J, Goh C, Low L, Hyakumura T, Tang M, et al.
Cereb Cortex
. 2013 Jul;
24(12):3289-300.
PMID: 23897647
Ubiquitin ligases of the Nedd4 family are important for axon and dendrite development, but little is known about their adaptor, Nedd4 family-interacting protein 1 (Ndfip1), that is responsible for their...
9.
Putz U, Howitt J, Doan A, Goh C, Low L, Silke J, et al.
Sci Signal
. 2012 Sep;
5(243):ra70.
PMID: 23012657
Exosomes are microvesicles of endosomal origin that are secreted, and their contents (proteins, lipids, DNA, or microRNAs) can alter the physiological states of recipient cells. We demonstrated that phosphatase and...
10.
Howitt J, Lackovic J, Low L, Naguib A, Macintyre A, Goh C, et al.
J Cell Biol
. 2012 Jan;
196(1):29-36.
PMID: 22213801
PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the major negative regulator of phosphatidylinositol 3-kinase signaling and has cell-specific functions including tumor suppression. Nuclear localization of PTEN is...