Seong-Seng Tan
Overview
Explore the profile of Seong-Seng Tan including associated specialties, affiliations and a list of published articles.
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Articles
73
Citations
1705
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Recent Articles
1.
Tong A, Chow Y, Xu K, Hardiman R, Schneider P, Tan S
Int J Oral Sci
. 2020 Feb;
12(1):7.
PMID: 32080164
Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this,...
2.
Wagle M, Marchingo J, Howitt J, Tan S, Goodnow C, Parish I
Cell Rep
. 2018 Jul;
24(3):577-584.
PMID: 30021156
Escape from peripheral tolerance checkpoints that control cytotoxic CD8 T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the...
3.
Ng H, Lee E, Cavanagh B, Britto J, Tan S
Exp Neurol
. 2017 May;
295:36-45.
PMID: 28511841
The two neuronal populations in the cortex, pyramidal neurons and interneurons, can be separated based on neurotransmitter identity, however, within this segregation a large degree of diversity exists. Investigations into...
4.
Sterzenbach U, Putz U, Low L, Silke J, Tan S, Howitt J
Mol Ther
. 2017 Apr;
25(6):1269-1278.
PMID: 28412169
Exosomes represent an attractive vehicle for the delivery of biomolecules. However, mechanisms for loading functional molecules into exosomes are relatively unexplored. Here we report the use of the evolutionarily conserved...
5.
Sturm K, Berger C, Zhou S, Dunwoodie S, Tan S, Tam P
Dev Genes Evol
. 2016 Oct;
206(6):377-388.
PMID: 27747399
The developmental potential of parthenogenetic embryonic stem (P-ES) cells was studied in teratomas and mouse chimaeras. Teratomas derived from P-ES cells contained a mixture of tissue types with variable proportions...
6.
Li S, Qu Z, Haas M, Ngo L, Heo Y, Kang H, et al.
Sci Rep
. 2016 Jul;
6:29514.
PMID: 27404227
Copy number variations to chromosome 21 (HSA21) cause intellectual disability and Down Syndrome, but our understanding of the HSA21 genetic factors which contribute to fetal brain development remains incomplete. Here,...
7.
8.
Lawrenson I, Krebs D, Linossi E, Zhang J, McLennan T, Collin C, et al.
Cereb Cortex
. 2015 Oct;
27(1):576-588.
PMID: 26503265
Mutations of the reelin gene cause severe defects in cerebral cortex development and profound intellectual impairment. While many aspects of the reelin signaling pathway have been identified, the molecular and...
9.
Howitt J, Low L, Putz U, Doan A, Lackovic J, Goh C, et al.
J Mol Cell Biol
. 2015 Mar;
7(2):119-31.
PMID: 25801959
Pten controls a signaling axis that is implicated to regulate cell proliferation, growth, survival, migration, and metabolism. The molecular mechanisms underlying the specificity of Pten responses to such diverse cellular...
10.
Low L, Chow Y, Li Y, Goh C, Putz U, Silke J, et al.
J Biol Chem
. 2015 Jan;
290(11):7141-50.
PMID: 25631046
During injury, cells are vulnerable to apoptosis from a variety of stress conditions including DNA damage causing double-stranded breaks. Without repair, these breaks lead to aberrations in DNA replication and...