Leonard P Freedman
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Explore the profile of Leonard P Freedman including associated specialties, affiliations and a list of published articles.
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49
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1831
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Recent Articles
21.
Cheskis B, Greger J, Cooch N, McNally C, Mclarney S, Lam H, et al.
Steroids
. 2008 Feb;
73(9-10):901-5.
PMID: 18261753
Estrogens play a critical role in the regulation of cellular proliferation, differentiation, and apoptosis. Evidence indicates that this regulation is mediated by a complex interface of direct control of gene...
22.
Krum S, Miranda-Carboni G, Hauschka P, Carroll J, Lane T, Freedman L, et al.
EMBO J
. 2008 Jan;
27(3):535-45.
PMID: 18219273
Estrogen deficiency in menopause is a major cause of osteoporosis in women. Estrogen acts to maintain the appropriate ratio between bone-forming osteoblasts and bone-resorbing osteoclasts in part through the induction...
23.
Kilbourne E, Moore W, Freedman L, Nagpal S
Curr Opin Investig Drugs
. 2007 Oct;
8(10):821-9.
PMID: 17907058
Androgens play an important role not only in male sexual differentiation, puberty, sexual behavior and spermatogenesis, but also in the maintenance of bone architecture and muscle mass and strength. For...
24.
Cheskis B, Greger J, Nagpal S, Freedman L
J Cell Physiol
. 2007 Sep;
213(3):610-7.
PMID: 17886255
By regulating activities and expression levels of key signaling molecules, estrogens control mechanisms that are responsible for crucial cellular functions. Ligand binding to estrogen receptor (ER) leads to conformational changes...
25.
Kitagawa H, Ray W, Glantschnig H, Nantermet P, Yu Y, Leu C, et al.
Mol Cell Biol
. 2007 Aug;
27(21):7486-96.
PMID: 17709391
The orphan nuclear receptor Nurr1 is essential for the development and maintenance of midbrain dopaminergic neurons, the cells that degenerate during Parkinson's disease, by promoting the transcription of genes involved...
26.
Greger J, Fursov N, Cooch N, Mclarney S, Freedman L, Edwards D, et al.
Mol Cell Biol
. 2006 Dec;
27(5):1904-13.
PMID: 17194752
Estrogen actions are mediated by a complex interface of direct control of gene expression (the so-called "genomic action") and by regulation of cell signaling/phosphorylation cascades, referred to as the "nongenomic,"...
27.
Cheskis B, Freedman L, Nagpal S
Curr Opin Investig Drugs
. 2006 Nov;
7(10):906-11.
PMID: 17086935
1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors. 1,25-(OH)2D3 is...
28.
Tobin J, Freedman L
Trends Endocrinol Metab
. 2006 Jul;
17(7):284-90.
PMID: 16870465
Nuclear receptors represent novel targets for the development of therapeutic agents for the treatment of numerous diseases, including type 2 diabetes, obesity dyslipidemia, atherosclerosis and the metabolic syndrome. There have...
29.
Lipfert L, Fisher J, Wei N, Scafonas A, Su Q, Yudkovitz J, et al.
Mol Endocrinol
. 2005 Oct;
20(3):516-33.
PMID: 16223974
Estrogen receptor alpha (ERalpha) serine 118 (Ser118) phosphorylation modulates activation function-1 (AF1) function. Correct positioning of helix 12 promotes agonist-dependent recruitment of cyclin-dependent kinase-7 to catalyze this event. In this...
30.
Leu C, Luegmayr E, Freedman L, Rodan G, Reszka A
Bone
. 2005 Sep;
38(5):628-36.
PMID: 16185944
Potent bisphosphonates (BPs) preferentially bind bone at sites of active osteoclastic bone resorption, where they are taken up by the osteoclast and inhibit resorption. We tested the hypothesis that BP...