Azriel Schmidt
Overview
Explore the profile of Azriel Schmidt including associated specialties, affiliations and a list of published articles.
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20
Citations
248
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Recent Articles
1.
Chisamore M, Gentile M, Dillon G, Baran M, Gambone C, Riley S, et al.
J Steroid Biochem Mol Biol
. 2016 Apr;
163:88-97.
PMID: 27106747
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male...
2.
Schmidt A, Meissner R, Gentile M, Chisamore M, Opas E, Scafonas A, et al.
J Steroid Biochem Mol Biol
. 2014 Feb;
143:29-39.
PMID: 24565564
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by...
3.
Brandish P, Anderson K, Baltus G, Bai C, Bungard C, Bunting P, et al.
Eur J Pharmacol
. 2013 Dec;
724:102-11.
PMID: 24374007
Glucocorticoids are used widely in the treatment of inflammatory diseases, but use is accompanied by a significant burden of adverse effects. It has been hypothesized that gene- and cell-specific regulation...
4.
Bai C, Flores O, Schmidt A
Expert Opin Drug Discov
. 2013 Mar;
2(5):725-37.
PMID: 23488961
Steroid hormone receptors belong to the nuclear receptor superfamily of ligand-dependent transcription factors and are the main effectors of steroid hormone action. A number of marketed drugs currently used in...
5.
Bungard C, Hartman G, Manikowski J, Perkins J, Bai C, Brandish P, et al.
Bioorg Med Chem
. 2011 Nov;
19(24):7374-86.
PMID: 22079253
A series of partial agonists of the Glucocorticoid Receptor were prepared targeting reduced transactivation activity, while maintaining significant transrepression activity. Incorporation of an ortho-aryl amide produced compounds with the desired...
6.
Schmidt A, Kimmel D, Bai C, Scafonas A, Rutledge S, Vogel R, et al.
J Biol Chem
. 2010 Apr;
285(22):17054-64.
PMID: 20356837
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or...
7.
Schmidt A, Harada S, Kimmel D, Bai C, Chen F, Rutledge S, et al.
J Biol Chem
. 2009 Oct;
284(52):36367-36376.
PMID: 19846549
Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks for unwanted effects including virilization and hypertrophy of reproductive organs. Selective Androgen Receptor Modulators...
8.
Opas E, Scafonas A, Nantermet P, Wilkening R, Birzin E, Wilkinson H, et al.
Maturitas
. 2009 Aug;
64(1):46-51.
PMID: 19679413
Objective: To test the role of ERbeta in the control of estrogen-dependent thermoregulation in rats. Methods: Test the ability of an ERbeta-selective ligand to suppress the elevation in basal rat...
9.
Mitchell H, Dankulich W, Hartman G, Prueksaritanont T, Schmidt A, Vogel R, et al.
J Med Chem
. 2009 Jul;
52(15):4578-81.
PMID: 19606870
A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles...
10.
Scafonas A, Reszka A, Kimmel D, Hou X, Su Q, Birzin E, et al.
J Steroid Biochem Mol Biol
. 2008 May;
110(3-5):197-206.
PMID: 18508261
Estradiol receptors (ER), ERalpha and ERbeta, are ligand-dependent transcription factors that regulate gene expression. Human and murine genetics suggest that ERalpha is the key target for estradiol action on bone,...