Leonard P Freedman
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Explore the profile of Leonard P Freedman including associated specialties, affiliations and a list of published articles.
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49
Citations
1831
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Recent Articles
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Freedman L, Inglese J
Cancer Res
. 2014 Jul;
74(15):4024-9.
PMID: 25035389
Research advances build upon the validity and reproducibility of previously published data and findings. Yet irreproducibility in basic biologic and preclinical research is pervasive in both academic and commercial settings....
13.
Shen Q, Bai Y, Chang K, Wang Y, Burris T, Freedman L, et al.
J Biol Chem
. 2011 Feb;
286(16):14554-63.
PMID: 21349840
Liver X receptors (LXRs) play a critical role in regulating lipid synthesis and transport in numerous tissues. In the skin, activation of LXR induces keratinocyte differentiation and improves epidermal permeability...
14.
Berrodin T, Shen Q, Quinet E, Yudt M, Freedman L, Nagpal S
Mol Pharmacol
. 2010 Sep;
78(6):1046-58.
PMID: 20837678
The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily that function as key transcriptional regulators of a number of biological processes, including cholesterol homeostasis, lipid...
15.
Schmidt A, Kimmel D, Bai C, Scafonas A, Rutledge S, Vogel R, et al.
J Biol Chem
. 2010 Apr;
285(22):17054-64.
PMID: 20356837
Selective androgen receptor modulators (SARMs) are androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially activate, or...
16.
Chang K, Wang Y, Oh I, Jenkins S, Freedman L, Thompson C, et al.
Mol Pharmacol
. 2010 Jan;
77(5):744-50.
PMID: 20110405
One of the many harmful factors faced by the skin is solar UV radiation, which damages skin by inducing chronic low-grade inflammation through increased expression of proinflammatory cytokines, metalloproteinases (MMPs)...
17.
Gentile M, Nantermet P, Vogel R, Phillips R, Holder D, Hodor P, et al.
J Mol Endocrinol
. 2009 Sep;
44(1):55-73.
PMID: 19726620
Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms...
18.
Berrodin T, Chang K, Komm B, Freedman L, Nagpal S
Mol Endocrinol
. 2008 Nov;
23(1):74-85.
PMID: 19036900
The use of estrogen-based therapies and the selective estrogen receptor (ER) modulator (SERM), raloxifene, which are approved for postmenopausal osteoporosis, is associated with side effects such as uterine/breast hyperproliferation, thromboembolism,...
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Chang K, Shen Q, Oh I, Jelinsky S, Jenkins S, Wang W, et al.
Mol Endocrinol
. 2008 Sep;
22(11):2407-19.
PMID: 18787039
Liver X receptors (LXRalpha and -beta) are liposensors that exert their metabolic effects by orchestrating the expression of macrophage genes involved in lipid metabolism and inflammation. LXRs are also expressed...