William J Ray
Overview
Explore the profile of William J Ray including associated specialties, affiliations and a list of published articles.
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73
Citations
1537
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Recent Articles
1.
Ralvenius W, Mungenast A, Woolf H, Huston M, Gillingham T, Godin S, et al.
J Exp Med
. 2023 Aug;
220(11).
PMID: 37642942
Pervasive neuroinflammation occurs in many neurodegenerative diseases, including Alzheimer's disease (AD). SPI1/PU.1 is a transcription factor located at a genome-wide significant AD-risk locus and its reduced expression is associated with...
2.
Le K, Soth M, Cross J, Liu G, Ray W, Ma J, et al.
J Med Chem
. 2023 Jul;
66(14):9954-9971.
PMID: 37436942
Chemotherapy-induced peripheral neuropathy (CIPN) is a major unmet medical need with limited treatment options. Despite different mechanisms of action, diverse chemotherapeutics can cause CIPN through a converged pathway─an active axon...
3.
Beckmann A, Ramirez P, Gamez M, Gonzalez E, De Mange J, Bieniek K, et al.
iScience
. 2023 Mar;
26(3):106152.
PMID: 36879821
In Alzheimer's disease, neurons acquire phenotypes that are also present in various cancers, including aberrant activation of the cell cycle. Unlike cancer, cell cycle activation in post-mitotic neurons is sufficient...
4.
Sohn C, Ma J, Ray W, Frost B
Front Aging
. 2023 Feb;
4:1058968.
PMID: 36756194
Neurodegenerative tauopathies, including Alzheimer's disease, are pathologically defined by the presence of aggregated forms of tau protein in brains of affected individuals. Previous studies report that the negative effects of...
5.
Ochoa E, Ramirez P, Gonzalez E, De Mange J, Ray W, Bieniek K, et al.
Sci Adv
. 2023 Jan;
9(1):eabq5423.
PMID: 36608133
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of "tauopathies," including Alzheimer's disease. Studies of human brain tissue and various model systems of...
6.
Ramirez P, Zuniga G, Sun W, Beckmann A, Ochoa E, DeVos S, et al.
Prog Neurobiol
. 2021 Oct;
208:102181.
PMID: 34670118
Transposable elements comprise almost half of the mammalian genome. A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation...
7.
Reichard H, Schiffer H, Monenschein H, Atienza J, Corbett G, Skaggs A, et al.
J Med Chem
. 2021 Jul;
64(15):11527-11542.
PMID: 34260228
The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance-use disorder. High-throughput screening and a...
8.
Ford M, Ray W, DiLuca E, Patek S, Santhanakrishnan A
Integr Comp Biol
. 2021 Jun;
61(5):1619-1630.
PMID: 34143201
Numerous aquatic invertebrates use drag-based metachronal rowing for swimming, in which closely spaced appendages are oscillated starting from the posterior, with each appendage phase-shifted in time relative to its neighbor....
9.
Ma J, Goodwani S, Acton P, Buggia-Prevot V, Kesler S, Jamal I, et al.
Pain
. 2021 Apr;
162(10):2599-2612.
PMID: 33872235
Chemotherapy-induced peripheral neuropathy (CIPN) and chemotherapy-induced cognitive impairments (CICI) are common, often severe neurotoxic side effects of cancer treatment that greatly reduce quality of life of cancer patients and survivors....
10.
Sun H, Monenschein H, Schiffer H, Reichard H, Kikuchi S, Hopkins M, et al.
J Med Chem
. 2021 Apr;
64(14):9875-9890.
PMID: 33861086
Parkinson's disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor...