Lee R Roberts
Overview
Explore the profile of Lee R Roberts including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
518
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Simpson J, Walker M, Sekela J, Ivey S, Jariwala P, Storch C, et al.
Cell Host Microbe
. 2024 May;
32(6):925-944.e10.
PMID: 38754417
Hormones and neurotransmitters are essential to homeostasis, and their disruptions are connected to diseases ranging from cancer to anxiety. The differential reactivation of endobiotic glucuronides by gut microbial β-glucuronidase (GUS)...
2.
Kasper S, Otten S, Squadroni B, Orr-Terry C, Kuang Y, Mussallem L, et al.
Bioeng Transl Med
. 2023 Sep;
8(5):e10542.
PMID: 37693049
Cyclic peptides are poised to target historically difficult to drug intracellular protein-protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have enabled...
3.
Kawamata Y, Ryu K, Hermann G, Sandahl A, Vantourout J, Olow A, et al.
Nat Chem
. 2023 Jun;
15(9):1267-1275.
PMID: 37322100
Target identification involves deconvoluting the protein target of a pharmacologically active, small-molecule ligand, a process that is critical for early drug discovery yet technically challenging. Photoaffinity labelling strategies have become...
4.
Oslund R, Reyes-Robles T, White C, Tomlinson J, Crotty K, Bowman E, et al.
Nat Chem Biol
. 2022 Jun;
18(8):850-858.
PMID: 35654846
The growing appreciation of immune cell-cell interactions within disease environments has led to extensive efforts to develop immunotherapies. However, characterizing complex cell-cell interfaces in high resolution remains challenging. Thus, technologies...
5.
Bissonnette N, Ryu K, Reyes-Robles T, Wilhelm S, Tomlinson J, Crotty K, et al.
Chembiochem
. 2020 Aug;
21(24):3555-3562.
PMID: 32749732
Despite the growing use of visible-light photochemistry in both chemistry and biology, no general low-heat photoreactor for use across these different disciplines exists. Herein, we describe the design and use...
6.
Jariwala P, Pellock S, Goldfarb D, Cloer E, Artola M, Simpson J, et al.
ACS Chem Biol
. 2019 Nov;
15(1):217-225.
PMID: 31774274
It is increasingly clear that interindividual variability in human gut microbial composition contributes to differential drug responses. For example, gastrointestinal (GI) toxicity is not observed in all patients treated with...
7.
Ervin S, Li H, Lim L, Roberts L, Liang X, Mani S, et al.
J Biol Chem
. 2019 Oct;
294(49):18586-18599.
PMID: 31636122
Gut microbial β-glucuronidase (GUS) enzymes have been suggested to be involved in the estrobolome, the collection of microbial reactions involving estrogens. Furthermore, bacterial GUS enzymes within the gastrointestinal tract have...
8.
Xu H, Roberts L, Chou S, Pierce B, Narayanan A, Jones L
Medchemcomm
. 2018 Aug;
8(4):767-770.
PMID: 30108795
Histone deacetylases (HDACs) regulate diverse cellular processes, and are promising targets for a number of diseases. Here we describe the design and utilization of a largazole-based chemical probe to quantitatively...
9.
Porter J, Watson J, Roberts L, Gill S, Groves H, Dhariwal J, et al.
J Antimicrob Chemother
. 2016 Aug;
71(10):2767-81.
PMID: 27494903
Background: Exacerbations of asthma and COPD are triggered by rhinoviruses. Uncontrolled inflammatory pathways, pathogenic bacterial burden and impaired antiviral immunity are thought to be important factors in disease severity and...
10.
Bhat A, Roberts L, Dwyer J
Eur J Med Chem
. 2014 Aug;
94:471-9.
PMID: 25109255
Peptide macrocycles represent a chemical space where the best of biological tools can synergize with the best of chemical approaches in the quest for leads against undruggable targets. Peptide macrocycles...