Matthew R Redinbo
Overview
Explore the profile of Matthew R Redinbo including associated specialties, affiliations and a list of published articles.
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147
Citations
5890
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Recent Articles
1.
Hillege L, Stevens M, Kristen P, de Vos-Geelen J, Penders J, Redinbo M, et al.
J Cancer Res Clin Oncol
. 2024 Nov;
150(11):495.
PMID: 39537966
Introduction: The human gut microbiota influence critical functions including the metabolism of nutrients, xenobiotics, and drugs. Gut microbial β-glucuronidases (GUS) enzymes facilitate the removal of glucuronic acid from various compounds,...
2.
Johnson R, Graboski A, Li F, Norris-Drouin J, Walton W, Arrowsmith C, et al.
J Med Chem
. 2024 Nov;
67(22):20056-20075.
PMID: 39508435
CHD1 is a chromodomain-helicase DNA-binding protein that preferentially recognizes di- and trimethylated lysine 4 on histone H3 (H3K4me2/3). Genetic studies have established CHD1 as a synthetic lethal target in phosphatase...
3.
Simke W, Walker M, Calderone L, Putz A, Patteson J, Vitro C, et al.
ACS Cent Sci
. 2024 Sep;
10(8):1524-1536.
PMID: 39220707
Heme oxygenase-like domain-containing oxidases (HDOs) are a rapidly expanding enzyme family that typically use dinuclear metal cofactors instead of heme. FlcD, an HDO from the opportunistic pathogen , catalyzes the...
4.
Graboski A, Simpson J, Pellock S, Mehta N, Creekmore B, Ariyarathna Y, et al.
RSC Chem Biol
. 2024 Aug;
5(9):853-865.
PMID: 39211470
The gut microbiome plays critical roles in human homeostasis, disease progression, and pharmacological efficacy through diverse metabolic pathways. Gut bacterial β-glucuronidase (GUS) enzymes reverse host phase 2 metabolism, in turn...
5.
Kerins A, Butler P, Riley R, Koszyczarek M, Smith C, Cruickshank F, et al.
Xenobiotica
. 2024 May;
54(6):304-315.
PMID: 38794972
studies using rat, mouse, and human microsomes and hepatocytes on the bacterial β-glucuronidase inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-ethoxyphenyl)-1-(2-hydroxyethyl)thiourea) (Inh 1) revealed extensive metabolism in all species.The intrinsic clearances of Inh 1 in human,...
6.
Simpson J, Walker M, Sekela J, Ivey S, Jariwala P, Storch C, et al.
Cell Host Microbe
. 2024 May;
32(6):925-944.e10.
PMID: 38754417
Hormones and neurotransmitters are essential to homeostasis, and their disruptions are connected to diseases ranging from cancer to anxiety. The differential reactivation of endobiotic glucuronides by gut microbial β-glucuronidase (GUS)...
7.
Cross T, Simpson A, Lin C, Hottmann N, Bhatt A, Pellock S, et al.
Gut Microbes
. 2023 Dec;
16(1):2295429.
PMID: 38153260
Women are at significantly greater risk of metabolic dysfunction after menopause, which subsequently leads to numerous chronic illnesses. The gut microbiome is associated with obesity and metabolic dysfunction, but its...
8.
Sarosh A, Kwong S, Jensen S, Northern F, Walton W, Eakes T, et al.
Plasmid
. 2023 Nov;
128:102708.
PMID: 37967733
The majority of large multiresistance plasmids of Staphylococcus aureus utilise a RepA_N-type replication initiation protein, the expression of which is regulated by a small antisense RNA (RNAI) that overlaps the...
9.
Carlson D, Kowalewski M, Bodoor K, Lietzan A, Hughes P, Gooden D, et al.
Cell Chem Biol
. 2023 Nov;
31(3):465-476.e12.
PMID: 37918401
Conventional antimicrobial discovery relies on targeting essential enzymes in pathogenic organisms, contributing to a paucity of new antibiotics to address resistant strains. Here, by targeting a non-essential enzyme, Borrelia burgdorferi...
10.
Graboski A, Kowalewski M, Simpson J, Cao X, Ha M, Zhang J, et al.
Cell Chem Biol
. 2023 Aug;
30(11):1402-1413.e7.
PMID: 37633277
Indoxyl sulfate is a microbially derived uremic toxin that accumulates in late-stage chronic kidney disease and contributes to both renal and cardiovascular toxicity. Indoxyl sulfate is generated by the metabolism...