Lars Eckmann
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Explore the profile of Lars Eckmann including associated specialties, affiliations and a list of published articles.
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158
Citations
10659
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Recent Articles
21.
Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, et al.
J Hepatol
. 2021 Dec;
76(4):788-799.
PMID: 34896404
Background & Aims: Studies investigating the gut-liver axis have largely focused on bacteria, whereas little is known about commensal fungi. We characterized fecal fungi in patients with non-alcoholic fatty liver...
22.
Natto M, Miyamoto Y, Munday J, AlSiari T, Al-Salabi M, Quashie N, et al.
Mol Microbiol
. 2021 Nov;
116(6):1489-1511.
PMID: 34738285
Trichomoniasis is a common and widespread sexually-transmitted infection, caused by the protozoan parasite Trichomonas vaginalis. T. vaginalis lacks the biosynthetic pathways for purines and pyrimidines, making nucleoside metabolism a drug...
23.
Marchelletta R, Krishnan M, Spalinger M, Placone T, Alvarez R, Sayoc-Becerra A, et al.
J Clin Invest
. 2021 Oct;
131(17).
PMID: 34623320
Genome-wide association studies revealed that loss-of-function mutations in protein tyrosine phosphatase non-receptor type 2 (PTPN2) increase the risk of developing chronic immune diseases, such as inflammatory bowel disease (IBD) and...
24.
Montenegro-Burke J, Kok B, Guijas C, Domingo-Almenara X, Moon C, Galmozzi A, et al.
Sci Signal
. 2021 Sep;
14(702):eabf6584.
PMID: 34582249
Untargeted metabolomics of disease-associated intestinal microbiota can detect quantitative changes in metabolite profiles and complement other methodologies to reveal the full effect of intestinal dysbiosis. Here, we used the T...
25.
Zhou D, Xue J, Miyamoto Y, Poulsen O, Eckmann L, Haddad G
Front Physiol
. 2021 Jul;
12:680275.
PMID: 34248668
The microbiota plays a critical role in regulating organismal health and response to environmental stresses. Intermittent hypoxia and hypercapnia, a condition that represents the main hallmark of obstructive sleep apnea...
26.
Miyamoto Y, Aggarwal S, Celaje J, Ihara S, Ang J, Eremin D, et al.
J Med Chem
. 2021 May;
64(10):6608-6620.
PMID: 33974434
causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clinical problem. The gold(I) complex, auranofin, is active...
27.
Natto M, Hulpia F, Kalkman E, Baillie S, Alhejeli A, Miyamoto Y, et al.
ACS Infect Dis
. 2021 May;
7(6):1752-1764.
PMID: 33974405
Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for high-throughput microplate-based screening under hypoxic...
28.
Den Hartog G, Butcher L, Ablack A, Pace L, Ablack J, Xiong R, et al.
Front Immunol
. 2021 Feb;
11:553994.
PMID: 33603730
Pathogenic intestinal bacteria lead to significant disease in humans. Here we investigated the role of the multifunctional protein, Apurinic/apyrimidinic endonuclease 1 (APE1), in regulating the internalization of bacteria into the...
29.
Spalinger M, Hai R, Li J, Santos A, Nordgren T, Tremblay M, et al.
bioRxiv
. 2020 Dec;
PMID: 33330862
Coronavirus disease (COVID-19), caused by SARS-CoV-2, has affected over 65 million individuals and killed over 1.5 million persons (December 8, 2020; www.who.int). While fatality rates are higher among the elderly...
30.
Xu F, Jimenez-Gonzalez A, Einarsson E, Astvaldsson A, Peirasmaki D, Eckmann L, et al.
Microb Genom
. 2020 Jul;
6(8).
PMID: 32618561
Diplomonad parasites of the genus have adapted to colonizing different hosts, most notably the intestinal tract of mammals. The human-pathogenic species, , has been extensively studied at the genome and...