Lars Eckmann
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Explore the profile of Lars Eckmann including associated specialties, affiliations and a list of published articles.
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158
Citations
10659
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Recent Articles
11.
Fajtova P, Hurysz B, Miyamoto Y, Serafim M, Jiang Z, Trujillo D, et al.
bioRxiv
. 2023 Apr;
PMID: 37066163
The protozoan parasite, (Tv) causes trichomoniasis, the most common, non-viral, sexually transmitted infection in the world. Only two closely related drugs are approved for its treatment. The accelerating emergence of...
12.
Canale V, Spalinger M, Alvarez R, Sayoc-Becerra A, Sanati G, Manz S, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Apr;
16(1):39-62.
PMID: 37030630
Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC)...
13.
Russell B, Brown S, Siguenza N, Mai I, Saran A, Lingaraju A, et al.
Cell
. 2022 Aug;
185(17):3263-3277.e15.
PMID: 35931082
Live bacterial therapeutics (LBTs) could reverse diseases by engrafting in the gut and providing persistent beneficial functions in the host. However, attempts to functionally manipulate the gut microbiome of conventionally...
14.
Rios-Covian D, Butcher L, Ablack A, Den Hartog G, Matsubara M, Ly H, et al.
Antioxid Redox Signal
. 2022 Jun;
38(1-3):183-197.
PMID: 35754343
Though best known for its role in oxidative DNA damage repair, apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that regulates multiple host responses during oxidative stress, including the reductive...
15.
Ihara S, Miyamoto Y, Le C, Tran V, Hanson E, Fischer M, et al.
PLoS Negl Trop Dis
. 2022 Apr;
16(4):e0010323.
PMID: 35468132
Giardia lamblia is a leading protozoal cause of diarrheal disease worldwide. Infection is associated with abdominal pain, malabsorption and weight loss, and protracted post-infectious syndromes. A human vaccine is not...
16.
Zhou J, Miyamoto Y, Ihara S, Kroll A, Nieskens N, Tran V, et al.
J Infect Dis
. 2022 Mar;
226(2):319-323.
PMID: 35262728
The protozoan pathogen Giardia lamblia is an important worldwide cause of diarrheal disease and malabsorption. Infection is managed with antimicrobials, although drug resistance and treatment failures are a clinical challenge....
17.
Krakovka S, Ribacke U, Miyamoto Y, Eckmann L, Svard S
Front Microbiol
. 2022 Feb;
13:834008.
PMID: 35222342
Metronidazole (MTZ) is a clinically important antimicrobial agent that is active against both bacterial and protozoan organisms. MTZ has been used extensively for more than 60 years and until now...
18.
Hartmann P, Duan Y, Miyamoto Y, Demir M, Lang S, Hasa E, et al.
Hepatol Int
. 2022 Jan;
16(2):359-370.
PMID: 35075592
Background: Obesity, non-alcoholic fatty liver disease (NAFLD) and its more advanced form non-alcoholic steatohepatitis (NASH) are important causes of morbidity and mortality worldwide. Bile acid dysregulation is a pivotal part...
19.
Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, et al.
Science
. 2022 Jan;
375(6577):214-221.
PMID: 35025664
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that have a central role in detecting...
20.
Dasgupta S, Maricic I, Tang J, Wandro S, Weldon K, Carpenter C, et al.
Immunohorizons
. 2021 Dec;
5(12):953-971.
PMID: 34911745
Lymphocytes within the intestinal epithelial layer (IEL) in mammals have unique composition compared with their counterparts in the lamina propria. Little is known about the role of some of the...