Larry L Luchsinger
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Explore the profile of Larry L Luchsinger including associated specialties, affiliations and a list of published articles.
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19
Citations
895
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Recent Articles
11.
Luchsinger L, Ransegnola B, Jin D, Muecksch F, Weisblum Y, Bao W, et al.
medRxiv
. 2020 Jun;
PMID: 32577675
The development of neutralizing antibodies (nAb) against SARS-CoV-2, following infection or vaccination, is likely to be critical for the development of sufficient population immunity to drive cessation of the COVID19...
12.
Luchsinger L, Strikoudis A, Danzl N, Bush E, Finlayson M, Satwani P, et al.
Cell Stem Cell
. 2019 Jun;
25(2):225-240.e7.
PMID: 31178255
The specific cellular physiology of hematopoietic stem cells (HSCs) is underexplored, and their maintenance in vitro remains challenging. We discovered that culture of HSCs in low calcium increased their maintenance...
13.
Corrigan D, Luchsinger L, Justino de Almeida M, Williams L, Strikoudis A, Snoeck H
J Clin Invest
. 2018 Jun;
128(8):3250-3264.
PMID: 29878897
PRDM16 is a transcriptional coregulator involved in translocations in acute myeloblastic leukemia (AML), myelodysplastic syndromes, and T acute lymphoblastic leukemia that is highly expressed in and required for the maintenance...
14.
Justino de Almeida M, Luchsinger L, Corrigan D, Williams L, Snoeck H
Cell Stem Cell
. 2017 Dec;
21(6):725-729.e4.
PMID: 29198942
Hematopoietic stem cells (HSCs) produce most cellular energy through glycolysis rather than through mitochondrial respiration. Consistent with this notion, mitochondrial mass has been reported to be low in HSCs. However,...
15.
Chen X, Deng H, Churchill M, Luchsinger L, Du X, Chu T, et al.
Cell Stem Cell
. 2017 Dec;
21(6):747-760.e7.
PMID: 29198940
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an...
16.
Adams W, Chen Y, Kratchmarov R, Yen B, Nish S, Lin W, et al.
Cell Rep
. 2016 Dec;
17(12):3142-3152.
PMID: 28009285
Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria. Disparate mitochondrial clearance impacts cell fate and reflects...
17.
Luchsinger L, Justino de Almeida M, Corrigan D, Mumau M, Snoeck H
Nature
. 2016 Jan;
529(7587):528-31.
PMID: 26789249
Haematopoietic stem cells (HSCs), which sustain production of all blood cell lineages, rely on glycolysis for ATP production, yet little attention has been paid to the role of mitochondria. Here...
18.
Kamezaki K, Luchsinger L, Snoeck H
Exp Hematol
. 2013 Nov;
42(3):192-203.e1.
PMID: 24269847
FLT3 is one of the most frequently mutated genes in acute leukemias. However, the role in leukemogenesis of wild-type (wt) FLT3, which is highly expressed in many hematologic malignancies, is...
19.
Luchsinger L, Patenaude C, Smith B, Layne M
J Biol Chem
. 2011 Nov;
286(51):44116-44125.
PMID: 22049076
Pulmonary fibrosis is characterized by the excessive deposition of a collagen-rich extracellular matrix. The accumulation of collagen within the lung interstitium leads to impaired respiratory function. Furthermore, smooth muscle actin-positive...