Kuzhuvelil B Harikumar
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Explore the profile of Kuzhuvelil B Harikumar including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Kurani H, Razavipour S, Harikumar K, Dunworth M, Ewald A, Nasir A, et al.
Clin Cancer Res
. 2022 Feb;
28(9):1948-1965.
PMID: 35135840
Purpose: Although chemotherapies kill most cancer cells, stem cell-enriched survivors seed metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are enriched for tumor stem cells. Here, we...
12.
James S, Aparna J, Babu A, Paul A, Babu Lankadasari M, Athira S, et al.
Biomolecules
. 2021 May;
11(5).
PMID: 33947113
Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different...
13.
Avni D, Harikumar K, Sanyal A, Spiegel S
FASEB J
. 2021 Feb;
35(3):e21415.
PMID: 33566377
Acute liver failure (ALF) causes severe liver dysfunction that can lead to multi-organ failure and death. Previous studies suggest that sphingosine kinase 1 (SphK1) protects against hepatocyte injury, yet not...
14.
Razavipour S, Harikumar K, Slingerland J
Cancer Res
. 2020 Apr;
80(17):3451-3458.
PMID: 32341036
p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other processes including cell migration and development independent of its cyclin-dependent kinase (CDK) inhibitory action. p27 is...
15.
Mohammed S, Vineetha N, James S, Aparna J, Babu Lankadasari M, Maeda T, et al.
FASEB J
. 2020 Jan;
34(3):4329-4347.
PMID: 31971297
Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report that sphingosine kinase 1 (SphK1) which produces...
16.
Babu Lankadasari M, Mukhopadhyay P, Mohammed S, Harikumar K
Mol Cancer
. 2019 Mar;
18(1):48.
PMID: 30925924
Among all the deadly cancers, pancreatic cancer ranks seventh in mortality. The absence of any grave symptoms coupled with the unavailability of early prognostic and diagnostic markers make the disease...
17.
Mohammed S, Vineetha N, James S, Aparna J, Babu Lankadasari M, Allegood J, et al.
FASEB J
. 2019 Mar;
33(6):7061-7071.
PMID: 30840833
Systemic lupus erythematosus is an autoimmune disease characterized by overproduction of type 1 IFN that causes multiple organ dysfunctions. Plasmacytoid dendritic cells (pDCs) that secrete large amounts of IFN have...
18.
Vijayan Y, Babu Lankadasari M, Harikumar K
Curr Top Med Chem
. 2019 Mar;
19(17):1512-1520.
PMID: 30827244
Sphingolipids are important constituents of the eukaryotic cell membrane which govern various signaling pathways related to different aspects of cell survival. Ceramide and Sphingosine are interconvertible sphingolipid metabolites, out of...
19.
Babu Lankadasari M, Aparna J, Mohammed S, James S, Aoki K, Binu V, et al.
Theranostics
. 2018 Aug;
8(14):3824-3840.
PMID: 30083262
Pancreatic cancer is associated with poor prognosis with a 5-year survival rate of less than 6%. Approximately 90% of pancreatic cancer patients harbor somatic mutations in the KRAS gene. Multiple...
20.
Majumder A, Syed K, Mukherjee A, Babu Lankadasari M, Azeez J, Sreeja S, et al.
Mol Cancer
. 2018 Mar;
17(1):76.
PMID: 29580241
DNA damage-specific histone chaperone Aprataxin PNK-like factor (APLF) regulates mesenchymal-to-epithelial transition (MET) during cellular reprogramming. We investigated the role of APLF in epithelial-to-mesenchymal transition (EMT) linked to breast cancer invasiveness...